9IGO
PR3 S203A I221N W222N G223T mutant in complex with the extracellular domain of CD177
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Myeloblastin | polymer | 238 | 26198.9 | 1 | UniProt (P24158) | Homo sapiens (human) | AGP7,C-ANCA antigen,Leukocyte proteinase 3,PR-3,PR3,Neutrophil proteinase 4,NP-4,P29,Wegener autoantigen |
| 2 | B (B) | CD177 antigen | polymer | 194 | 21290.3 | 1 | UniProt (Q8N6Q3) | Homo sapiens (human) | Human neutrophil alloantigen 2a,HNA-2a,NB1 glycoprotein,NB1 GP,Polycythemia rubra vera protein 1,PRV-1 |
| 3 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H, L (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | I, J, K (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 8 | M, N (A, B) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A: 28 - 256 (UniProt: P24158)
B: 22 - 206 (UniProt: Q8N6Q3)
| PDB | External Database | Details |
|---|---|---|
| Ile 119 | Val 119 | variant |
| Ala 203 | Ser 203 | engineered mutation |
| Asn 221 | Ile 221 | engineered mutation |
| Gly 222 | Trp 222 | engineered mutation |
| Thr 223 | Gly 223 | engineered mutation |
| Gly 257 | - | expression tag |
| Thr 258 | - | expression tag |
| Lys 259 | - | expression tag |
| His 260 | - | expression tag |
| His 261 | - | expression tag |
| His 262 | - | expression tag |
| His 263 | - | expression tag |
| His 264 | - | expression tag |
| His 265 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 207 | - | expression tag |
| Thr 208 | - | expression tag |
| Lys 209 | - | expression tag |
| His 210 | - | expression tag |
| His 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| His 215 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47489.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 839.2 | |
| All* | Total formula weight | 49177.2 |
