9IGO
PR3 S203A I221N W222N G223T mutant in complex with the extracellular domain of CD177
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006509 | biological_process | membrane protein ectodomain proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0019730 | biological_process | antimicrobial humoral response |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0044853 | cellular_component | plasma membrane raft |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045217 | biological_process | cell-cell junction maintenance |
| A | 0050765 | biological_process | negative regulation of phagocytosis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072672 | biological_process | neutrophil extravasation |
| A | 0097029 | biological_process | mature conventional dendritic cell differentiation |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU67-CYS72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 220 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8757293","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FUJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
