9FOY

Ternary complex of a Mycobacterium tuberculosis DNA gyrase core fusion with DNA and the inhibitor AMK32b

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	DNA gyrase subunit B,DNA gyrase subunit A	polymer	756	84383.9	2	UniProt (P9WG45) UniProt (P9WG47) Pfam (PF01751) Pfam (PF00986) Pfam (PF00521)	Mycobacterium tuberculosis H37Rv	Type IIA topoisomerase subunit GyrA
2	C, E (E, G)	DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G)-3')	polymer	8	2451.6	2		Mycobacterium tuberculosis H37Rv
3	D, F (F, H)	DNA (5'-D(P*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3')	polymer	12	3638.4	2		synthetic construct
4	G (H)	(1~{S})-2-[4-[[4-bromanyl-3,5-bis(fluoranyl)phenyl]methylamino]cyclohexyl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol	non-polymer		506.4	1	Chemie (A1ID8)
5	H (H)	(1~{R})-2-[4-[[4-bromanyl-3,5-bis(fluoranyl)phenyl]methylamino]cyclohexyl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol	non-polymer		506.4	1	Chemie (A1ID9)

Sequence modifications

A, B: 426 - 1001 (UniProt: P9WG45)

PDB	External Database	Details
Ser 423	-	expression tag
Asn 424	-	expression tag
Ala 425	-	expression tag

A, B: 1002 - 1500 (UniProt: P9WG47)

PDB	External Database	Details
Ile 1501	-	expression tag
Gly 1502	-	expression tag
Ser 1503	-	expression tag
Gly 1504	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	180947.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1012.8
All*	Total formula weight	181960.5

*Water molecules are not included.