9FJF
Lysosomal transporting complex of beta-glucocerebrosidase (GCase) and lysosomal integral membrane protein 2 (LIMP-2) with bound Pro-macrobodies (Combined focus map)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysosome membrane protein 2 | polymer | 391 | 44862.7 | 1 | UniProt (Q14108) Pfam (PF01130) | Homo sapiens (human) | 85 kDa lysosomal membrane sialoglycoprotein,LGP85,CD36 antigen-like 2,Lysosome membrane protein II,LIMP II,Scavenger receptor class B member 2 |
| 2 | B (B) | Lysosomal acid glucosylceramidase | polymer | 497 | 55659.2 | 1 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) | Homo sapiens (human) | Lysosomal acid GCase,Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,Cholesterol glucosyltransferase,SGTase,Cholesteryl-beta-glucosidase,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase |
| 3 | C (C) | Nanobody Nb1 | polymer | 130 | 14409.8 | 1 | synthetic construct | ||
| 4 | D (D) | Nanobody Nb6 | polymer | 121 | 13145.6 | 1 | synthetic construct | ||
| 5 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | F, G, H, J (F, G, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 7 | I (I) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 8 | K, L, M, N, P... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 9 | O, S, T, U (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) | |||
| 10 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128077.3 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3195.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2329.4 | |
| All* | Total formula weight | 133601.7 |
