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9FJF

Lysosomal transporting complex of beta-glucocerebrosidase (GCase) and lysosomal integral membrane protein 2 (LIMP-2) with bound Pro-macrobodies (Combined focus map)

Functional Information from GO Data
ChainGOidnamespacecontents
B0000423biological_processmitophagy
B0004336molecular_functiongalactosylceramidase activity
B0004348molecular_functionglucosylceramidase activity
B0005102molecular_functionsignaling receptor binding
B0005124molecular_functionscavenger receptor binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0006629biological_processlipid metabolic process
B0006665biological_processsphingolipid metabolic process
B0006678biological_processglucosylceramide metabolic process
B0006680biological_processglucosylceramide catabolic process
B0006914biological_processautophagy
B0007005biological_processmitochondrion organization
B0007040biological_processlysosome organization
B0007417biological_processcentral nervous system development
B0008202biological_processsteroid metabolic process
B0008203biological_processcholesterol metabolic process
B0008340biological_processdetermination of adult lifespan
B0008422molecular_functionbeta-glucosidase activity
B0009267biological_processcellular response to starvation
B0009268biological_processresponse to pH
B0010605biological_processnegative regulation of macromolecule metabolic process
B0014004biological_processmicroglia differentiation
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0019882biological_processantigen processing and presentation
B0019915biological_processlipid storage
B0021694biological_processcerebellar Purkinje cell layer formation
B0021859biological_processpyramidal neuron differentiation
B0022904biological_processrespiratory electron transport chain
B0023021biological_processtermination of signal transduction
B0030259biological_processlipid glycosylation
B0031175biological_processneuron projection development
B0031333biological_processnegative regulation of protein-containing complex assembly
B0032006biological_processregulation of TOR signaling
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032715biological_processnegative regulation of interleukin-6 production
B0033077biological_processT cell differentiation in thymus
B0033574biological_processresponse to testosterone
B0042176biological_processregulation of protein catabolic process
B0042391biological_processregulation of membrane potential
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043202cellular_componentlysosomal lumen
B0043409biological_processnegative regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0043627biological_processresponse to estrogen
B0046512biological_processsphingosine biosynthetic process
B0046513biological_processceramide biosynthetic process
B0046527molecular_functionglucosyltransferase activity
B0048469biological_processcell maturation
B0048854biological_processbrain morphogenesis
B0048872biological_processhomeostasis of number of cells
B0050295molecular_functionsteryl-beta-glucosidase activity
B0050728biological_processnegative regulation of inflammatory response
B0050877biological_processnervous system process
B0050905biological_processneuromuscular process
B0051246biological_processregulation of protein metabolic process
B0051247biological_processpositive regulation of protein metabolic process
B0051248biological_processnegative regulation of protein metabolic process
B0051402biological_processneuron apoptotic process
B0061436biological_processestablishment of skin barrier
B0061518biological_processmicroglial cell proliferation
B0061744biological_processmotor behavior
B0070062cellular_componentextracellular exosome
B0071356biological_processcellular response to tumor necrosis factor
B0071425biological_processhematopoietic stem cell proliferation
B0071548biological_processresponse to dexamethasone
B0072676biological_processlymphocyte migration
B0097066biological_processresponse to thyroid hormone
B0098773biological_processskin epidermis development
B1901805biological_processbeta-glucoside catabolic process
B1903052biological_processpositive regulation of proteolysis involved in protein catabolic process
B1904457biological_processpositive regulation of neuronal action potential
B1905037biological_processautophagosome organization
B1905091biological_processpositive regulation of type 2 mitophagy
B1905146biological_processlysosomal protein catabolic process
B1905165biological_processregulation of lysosomal protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24162852
ChainResidueDetails
AASN45
AASN68
AASN206
AASN304
AASN325

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN105

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24162852
ChainResidueDetails
AASN224

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24162852
ChainResidueDetails
AASN249

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:24162852
ChainResidueDetails
AASN412

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218
ChainResidueDetails
BASN270

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN462

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 764
ChainResidueDetails
BGLU235activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
BGLU340covalently attached, nucleofuge, nucleophile
BCYS342electrostatic stabiliser
BASN370

236371

PDB entries from 2025-05-21

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