9EO4

Outward-open structure of human dopamine transporter bound to cocaine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Sodium-dependent dopamine transporter	polymer	660	72209.3	1	UniProt (Q01959) Pfam (PF00209) In PDB	Homo sapiens (human)	DA transporter,DAT,Solute carrier family 6 member 3
2	B	CHOLESTEROL	non-polymer		386.7	3	Chemie (CLR)
3	B	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01)
4	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	B	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	B	COCAINE	non-polymer		303.4	1	Chemie (COC)
7		water	water		18.0	4	Chemie (HOH)

Sequence modifications

B: 1 - 620 (UniProt: Q01959)

PDB	External Database	Details
Gly 621	-	expression tag
Gly 622	-	expression tag
Gly 623	-	expression tag
Ser 624	-	expression tag
Gly 625	-	expression tag
Gly 626	-	expression tag
Gly 627	-	expression tag
Ser 628	-	expression tag
Gly 629	-	expression tag
Gly 630	-	expression tag
Ser 631	-	expression tag
Ala 632	-	expression tag
Trp 633	-	expression tag
Ser 634	-	expression tag
His 635	-	expression tag
Pro 636	-	expression tag
Gln 637	-	expression tag
Phe 638	-	expression tag
Glu 639	-	expression tag
Lys 640	-	expression tag
Gly 641	-	expression tag
Gly 642	-	expression tag
Gly 643	-	expression tag
Ser 644	-	expression tag
Gly 645	-	expression tag
Gly 646	-	expression tag
Gly 647	-	expression tag
Ser 648	-	expression tag
Gly 649	-	expression tag
Gly 650	-	expression tag
Ser 651	-	expression tag
Ala 652	-	expression tag
Trp 653	-	expression tag
Ser 654	-	expression tag
His 655	-	expression tag
Pro 656	-	expression tag
Gln 657	-	expression tag
Phe 658	-	expression tag
Glu 659	-	expression tag
Lys 660	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	72209.3
Non-Polymers*	Number of molecules	7
	Total formula weight	2008.5
All*	Total formula weight	74217.8

*Water molecules are not included.