9EO4
Outward-open structure of human dopamine transporter bound to cocaine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Sodium-dependent dopamine transporter | polymer | 660 | 72209.3 | 1 | UniProt (Q01959) Pfam (PF00209) | Homo sapiens (human) | DA transporter,DAT,Solute carrier family 6 member 3 |
| 2 | B, D, E (B) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 3 | C (B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 4 | F (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | H (B) | COCAINE | non-polymer | 303.4 | 1 | Chemie (COC) PubChem (2826) PubChem (5760) PubChem (44246523) PubChem (44281182) PubChem (44382114) PubChem (44382176) PubChem (44382277) PubChem (44382278) PubChem (122142) PubChem (135184) PubChem (50897619) PubChem (56840956) PubChem (165376) PubChem (44279116) PubChem (439497) PubChem (644005) PubChem (644017) PubChem (644018) PubChem (644271) PubChem (5872) PubChem (446220) PubChem (497304) PubChem (638023) PubChem (5315982) PubChem (6101676) PubChem (6338296) PubChem (6432459) PubChem (6432481) PubChem (98078900) PubChem (6918958) PubChem (9861246) PubChem (12305901) PubChem (10136514) PubChem (11779748) PubChem (13006129) PubChem (15558678) PubChem (15558680) PubChem (15558681) PubChem (15558688) PubChem (15558693) PubChem (124909386) PubChem (134972500) PubChem (173815154) | |||
| 7 | I (B) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
B: 1 - 620 (UniProt: Q01959)
| PDB | External Database | Details |
|---|---|---|
| Gly 621 | - | expression tag |
| Gly 622 | - | expression tag |
| Gly 623 | - | expression tag |
| Ser 624 | - | expression tag |
| Gly 625 | - | expression tag |
| Gly 626 | - | expression tag |
| Gly 627 | - | expression tag |
| Ser 628 | - | expression tag |
| Gly 629 | - | expression tag |
| Gly 630 | - | expression tag |
| Ser 631 | - | expression tag |
| Ala 632 | - | expression tag |
| Trp 633 | - | expression tag |
| Ser 634 | - | expression tag |
| His 635 | - | expression tag |
| Pro 636 | - | expression tag |
| Gln 637 | - | expression tag |
| Phe 638 | - | expression tag |
| Glu 639 | - | expression tag |
| Lys 640 | - | expression tag |
| Gly 641 | - | expression tag |
| Gly 642 | - | expression tag |
| Gly 643 | - | expression tag |
| Ser 644 | - | expression tag |
| Gly 645 | - | expression tag |
| Gly 646 | - | expression tag |
| Gly 647 | - | expression tag |
| Ser 648 | - | expression tag |
| Gly 649 | - | expression tag |
| Gly 650 | - | expression tag |
| Ser 651 | - | expression tag |
| Ala 652 | - | expression tag |
| Trp 653 | - | expression tag |
| Ser 654 | - | expression tag |
| His 655 | - | expression tag |
| Pro 656 | - | expression tag |
| Gln 657 | - | expression tag |
| Phe 658 | - | expression tag |
| Glu 659 | - | expression tag |
| Lys 660 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 72209.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2008.5 | |
| All* | Total formula weight | 74217.8 |
