9EO4
Outward-open structure of human dopamine transporter bound to cocaine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001504 | biological_process | neurotransmitter uptake |
| B | 0002020 | molecular_function | protease binding |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005326 | molecular_function | neurotransmitter transmembrane transporter activity |
| B | 0005330 | molecular_function | dopamine:sodium symporter activity |
| B | 0005334 | molecular_function | norepinephrine:sodium symporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006836 | biological_process | neurotransmitter transport |
| B | 0006865 | biological_process | amino acid transport |
| B | 0007595 | biological_process | lactation |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0008504 | molecular_function | monoamine transmembrane transporter activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009986 | cellular_component | cell surface |
| B | 0010039 | biological_process | response to iron ion |
| B | 0014070 | biological_process | response to organic cyclic compound |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015844 | biological_process | monoamine transport |
| B | 0015872 | biological_process | dopamine transport |
| B | 0015874 | biological_process | norepinephrine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016600 | cellular_component | flotillin complex |
| B | 0021984 | biological_process | adenohypophysis development |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030424 | cellular_component | axon |
| B | 0032809 | cellular_component | neuronal cell body membrane |
| B | 0035094 | biological_process | response to nicotine |
| B | 0035240 | molecular_function | dopamine binding |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0040018 | biological_process | positive regulation of multicellular organism growth |
| B | 0042053 | biological_process | regulation of dopamine metabolic process |
| B | 0042220 | biological_process | response to cocaine |
| B | 0042416 | biological_process | dopamine biosynthetic process |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0042734 | cellular_component | presynaptic membrane |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043176 | molecular_function | amine binding |
| B | 0043679 | cellular_component | axon terminus |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045121 | cellular_component | membrane raft |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0045471 | biological_process | response to ethanol |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050890 | biological_process | cognition |
| B | 0051583 | biological_process | dopamine uptake involved in synaptic transmission |
| B | 0051591 | biological_process | response to cAMP |
| B | 0051620 | biological_process | norepinephrine uptake |
| B | 0051721 | molecular_function | protein phosphatase 2A binding |
| B | 0060134 | biological_process | prepulse inhibition |
| B | 0090494 | biological_process | dopamine uptake |
| B | 0098691 | cellular_component | dopaminergic synapse |
| B | 1901363 | molecular_function | heterocyclic compound binding |
| B | 1990384 | biological_process | hyaloid vascular plexus regression |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF |
| Chain | Residue | Details |
| B | TRP84-PHE98 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfsSFTteLPWihCnnswNS |
| Chain | Residue | Details |
| B | TYR166-SER186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-ASP68 | |
| B | LYS579-VAL620 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE69-LEU89 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY96-MET116 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY140-ILE160 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA161-ARG237 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| B | TRP238-TRP256 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL265-LEU282 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL318-TYR335 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE347-LEU368 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU401-ILE420 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU447-THR465 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY481-VAL501 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU522-VAL541 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU560-TYR578 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
| Chain | Residue | Details |
| B | GLY75 | |
| B | ALA77 | |
| B | VAL78 | |
| B | ASN82 | |
| B | SER321 | |
| B | ASN353 | |
| B | LEU418 | |
| B | ASP421 | |
| B | SER422 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | SITE: Contributes to high-affinity binding to cocaine => ECO:0000250|UniProtKB:Q61327 |
| Chain | Residue | Details |
| B | PHE105 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN181 | |
| B | ASN188 | |
| B | ASN205 |
