9EMA

RUVBL1/2 in complex with ATP and CB-6644 inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	RuvB-like 1	polymer	459	50579.2	3	UniProt (Q9Y265) Pfam (PF06068) Pfam (PF17856) In PDB	Homo sapiens (human)	49 kDa TATA box-binding protein-interacting protein,49 kDa TBP-interacting protein,54 kDa erythrocyte cytosolic protein,ECP-54,INO80 complex subunit H,Nuclear matrix protein 238,NMP 238,Pontin 52,TIP49a,TIP60-associated protein 54-alpha,TAP54-alpha
2	D, E, F	RuvB-like 2	polymer	764	85101.0	3	UniProt (Q9Y230) Pfam (PF06068) Pfam (PF17856) In PDB	Homo sapiens (human)	48 kDa TATA box-binding protein-interacting protein,48 kDa TBP-interacting protein,51 kDa erythrocyte cytosolic protein,ECP-51,INO80 complex subunit J,Repressing pontin 52,Reptin 52,TIP49b,TIP60-associated protein 54-beta,TAP54-beta
3	A, B, C, D, E...	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	6	Chemie (ATP)
4	A, B, C	5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide	non-polymer		573.1	3	Chemie (A1H5V)
5	D, E, F	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)

Sequence modifications

A, B, C: 1 - 456 (UniProt: Q9Y265)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

D, E, F: 1 - 463 (UniProt: Q9Y230)

PDB	External Database	Details
Met -17	-	initiating methionine
Ala -16	-	expression tag
Asp -15	-	expression tag
Leu -14	-	expression tag
Asn -13	-	expression tag
Trp -12	-	expression tag
Ile -11	-	expression tag
Ser -10	-	expression tag
Ala -9	-	expression tag
Gly -8	-	expression tag
His -7	-	expression tag
Ala -6	-	expression tag
Ile -5	-	expression tag
Ala -4	-	expression tag
Asp -3	-	expression tag
Val -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag

D, E, F: 464 - 746 (UniProt: Q9Y230)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	407040.5
Non-Polymers*	Number of molecules	13
	Total formula weight	4859.5
All*	Total formula weight	411899.9

*Water molecules are not included.