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9EMA

RUVBL1/2 in complex with ATP and CB-6644 inhibitor

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000492biological_processbox C/D snoRNP assembly
A0000723biological_processtelomere maintenance
A0000786cellular_componentnucleosome
A0000812cellular_componentSwr1 complex
A0001094molecular_functionTFIID-class transcription factor complex binding
A0003678molecular_functionDNA helicase activity
A0003713molecular_functiontranscription coactivator activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006310biological_processDNA recombination
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0007283biological_processspermatogenesis
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017025molecular_functionTBP-class protein binding
A0031011cellular_componentIno80 complex
A0032508biological_processDNA duplex unwinding
A0033044biological_processregulation of chromosome organization
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0042981biological_processregulation of apoptotic process
A0043531molecular_functionADP binding
A0045296molecular_functioncadherin binding
A0045739biological_processpositive regulation of DNA repair
A0045893biological_processpositive regulation of DNA-templated transcription
A0045995biological_processregulation of embryonic development
A0050821biological_processprotein stabilization
A0051117molecular_functionATPase binding
A0051276biological_processchromosome organization
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060382biological_processregulation of DNA strand elongation
A0070062cellular_componentextracellular exosome
A0071339cellular_componentMLL1 complex
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097255cellular_componentR2TP complex
A0101031cellular_componentprotein folding chaperone complex
A0120293cellular_componentdynein axonemal particle
A1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
A1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
A1990904cellular_componentribonucleoprotein complex
A2000779biological_processregulation of double-strand break repair
B0000492biological_processbox C/D snoRNP assembly
B0000723biological_processtelomere maintenance
B0000786cellular_componentnucleosome
B0000812cellular_componentSwr1 complex
B0001094molecular_functionTFIID-class transcription factor complex binding
B0003678molecular_functionDNA helicase activity
B0003713molecular_functiontranscription coactivator activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006310biological_processDNA recombination
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0007283biological_processspermatogenesis
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017025molecular_functionTBP-class protein binding
B0031011cellular_componentIno80 complex
B0032508biological_processDNA duplex unwinding
B0033044biological_processregulation of chromosome organization
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0042981biological_processregulation of apoptotic process
B0043531molecular_functionADP binding
B0045296molecular_functioncadherin binding
B0045739biological_processpositive regulation of DNA repair
B0045893biological_processpositive regulation of DNA-templated transcription
B0045995biological_processregulation of embryonic development
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0051276biological_processchromosome organization
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060382biological_processregulation of DNA strand elongation
B0070062cellular_componentextracellular exosome
B0071339cellular_componentMLL1 complex
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0097255cellular_componentR2TP complex
B0101031cellular_componentprotein folding chaperone complex
B0120293cellular_componentdynein axonemal particle
B1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
B1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
B1990904cellular_componentribonucleoprotein complex
B2000779biological_processregulation of double-strand break repair
C0000492biological_processbox C/D snoRNP assembly
C0000723biological_processtelomere maintenance
C0000786cellular_componentnucleosome
C0000812cellular_componentSwr1 complex
C0001094molecular_functionTFIID-class transcription factor complex binding
C0003678molecular_functionDNA helicase activity
C0003713molecular_functiontranscription coactivator activity
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006310biological_processDNA recombination
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0007283biological_processspermatogenesis
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017025molecular_functionTBP-class protein binding
C0031011cellular_componentIno80 complex
C0032508biological_processDNA duplex unwinding
C0033044biological_processregulation of chromosome organization
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0042981biological_processregulation of apoptotic process
C0043531molecular_functionADP binding
C0045296molecular_functioncadherin binding
C0045739biological_processpositive regulation of DNA repair
C0045893biological_processpositive regulation of DNA-templated transcription
C0045995biological_processregulation of embryonic development
C0050821biological_processprotein stabilization
C0051117molecular_functionATPase binding
C0051276biological_processchromosome organization
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0060382biological_processregulation of DNA strand elongation
C0070062cellular_componentextracellular exosome
C0071339cellular_componentMLL1 complex
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0097255cellular_componentR2TP complex
C0101031cellular_componentprotein folding chaperone complex
C0120293cellular_componentdynein axonemal particle
C1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
C1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
C1990904cellular_componentribonucleoprotein complex
C2000779biological_processregulation of double-strand break repair
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
DGLY77
EGLY77
FGLY77

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.14, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
DALA2
EALA2
FALA2

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER720
ESER720
FSER720

site_idSWS_FT_FI4
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS9
FLYS727
FLYS739
ALYS445
DLYS727
DLYS739
ELYS9
CLYS445
ELYS727
ELYS739
FLYS9

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS225
BLYS225
CLYS225

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PDB entries from 2024-07-24

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