9DTS
Crystal structure of the human eIF4A1/AMPPNP/amidino-rocaglate/polypurine RNA complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Eukaryotic initiation factor 4A-I | polymer | 388 | 44231.8 | 4 | UniProt (P60842) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | eIF-4A-I,eIF4A-I,ATP-dependent RNA helicase eIF4A-1 |
| 2 | E, F, G, H (W, X, Y, Z) | RNA (5'-R(P*AP*GP*AP*GP*AP*GP*AP*G)-3') | polymer | 10 | 3327.1 | 4 | Homo sapiens | ||
| 3 | I, K, M, O (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | J, L, N, P (A, B, C, D) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
| 5 | Q, R, S, T (D, W, X, Y) | (3aR,4R,5S,5aR,10bR)-3a-hydroxy-N,8,10-trimethoxy-5a-(4-methoxyphenyl)-N,2-dimethyl-5-phenyl-3a,4,5,5a-tetrahydro-1H-[1]benzofuro[3',2':1,5]cyclopenta[1,2-d]imidazole-4-carboxamide | non-polymer | 559.6 | 4 | Chemie (A1BB1) | |||
| 6 | AA, BA, U, V, W... (Y, Z, A, B, C...) | water | water | 18.0 | 899 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 21 - 406 (UniProt: P60842)
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | - | cloning artifact |
| Ser 20 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 190235.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4360.4 | |
| All* | Total formula weight | 194595.9 |
