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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9DTS

Crystal structure of the human eIF4A1/AMPPNP/amidino-rocaglate/polypurine RNA complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000339molecular_functionRNA cap binding
A0002183biological_processcytoplasmic translational initiation
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003725molecular_functiondouble-stranded RNA binding
A0003729molecular_functionmRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0008135molecular_functiontranslation factor activity, RNA binding
A0010494cellular_componentcytoplasmic stress granule
A0016020cellular_componentmembrane
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0070062cellular_componentextracellular exosome
A0097165cellular_componentnuclear stress granule
B0000166molecular_functionnucleotide binding
B0000339molecular_functionRNA cap binding
B0002183biological_processcytoplasmic translational initiation
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003725molecular_functiondouble-stranded RNA binding
B0003729molecular_functionmRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0008135molecular_functiontranslation factor activity, RNA binding
B0010494cellular_componentcytoplasmic stress granule
B0016020cellular_componentmembrane
B0016281cellular_componenteukaryotic translation initiation factor 4F complex
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0070062cellular_componentextracellular exosome
B0097165cellular_componentnuclear stress granule
C0000166molecular_functionnucleotide binding
C0000339molecular_functionRNA cap binding
C0002183biological_processcytoplasmic translational initiation
C0003676molecular_functionnucleic acid binding
C0003723molecular_functionRNA binding
C0003724molecular_functionRNA helicase activity
C0003725molecular_functiondouble-stranded RNA binding
C0003729molecular_functionmRNA binding
C0003743molecular_functiontranslation initiation factor activity
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0008135molecular_functiontranslation factor activity, RNA binding
C0010494cellular_componentcytoplasmic stress granule
C0016020cellular_componentmembrane
C0016281cellular_componenteukaryotic translation initiation factor 4F complex
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048471cellular_componentperinuclear region of cytoplasm
C0070062cellular_componentextracellular exosome
C0097165cellular_componentnuclear stress granule
D0000166molecular_functionnucleotide binding
D0000339molecular_functionRNA cap binding
D0002183biological_processcytoplasmic translational initiation
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0003725molecular_functiondouble-stranded RNA binding
D0003729molecular_functionmRNA binding
D0003743molecular_functiontranslation initiation factor activity
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0008135molecular_functiontranslation factor activity, RNA binding
D0010494cellular_componentcytoplasmic stress granule
D0016020cellular_componentmembrane
D0016281cellular_componenteukaryotic translation initiation factor 4F complex
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048471cellular_componentperinuclear region of cytoplasm
D0070062cellular_componentextracellular exosome
D0097165cellular_componentnuclear stress granule
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
AVAL180-LEU188
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues684
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues322
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues112
DetailsMotif: {"description":"Q motif"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsMotif: {"description":"DEAD box"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60843","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P60843","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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