9D7Q

Water and chloride as allosteric inhibitors in WNK kinase osmosensing

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase WNK3	polymer	280	32064.2	2	UniProt (Q9BYP7) Pfam (PF00069)	Homo sapiens (human)	Protein kinase lysine-deficient 3,Protein kinase with no lysine 3
2	C, D (A, B)	water	water		18.0	109	Chemie (HOH)

Sequence modifications

A, B: 130 - 409 (UniProt: Q9BYP7)

PDB	External Database	Details
Asn 279	Asp 279	conflict
Ala 314	Glu 314	engineered mutation
Phe 325	Tyr 325	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64128.3
All*	Total formula weight	64128.3

*Water molecules are not included.