9D7Q

Water and chloride as allosteric inhibitors in WNK kinase osmosensing

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKcnNIFI

Chain	Residue	Details
A	ILE271-ILE283

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q9JIH7

Chain	Residue	Details
A	ASP294
B	ASP294

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9H4A3

Chain	Residue	Details
A	THR227
A	LYS277
B	THR227
B	LYS277

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:Q9JIH7

Chain	Residue	Details
A	SER304
B	SER304

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:33439774

Chain	Residue	Details
A	SER308
B	SER308

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