9CZE
High-Resolution Structure of Human DHODH for Molecular Replacement in Fragment Screening Campaign
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 368 | 39943.6 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (human) | DHOdehase,Dihydroorotate oxidase |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C, D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) PubChem (679) | |||
| 4 | E, F, G, H, I... (A) | ACETIC ACID | non-polymer | 60.1 | 6 | Chemie (ACY) | |||
| 5 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | L (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 7 | M (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (8965) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (23585816) PubChem (51435500) PubChem (51435503) PubChem (15559251) | |||
| 8 | N (A) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 30 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Ser 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39943.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1260.5 | |
| All* | Total formula weight | 41204.1 |
