9BJU
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | Elongin-B | polymer | 104 | 11748.4 | 4 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B, E, H, K (B, E, H, K) | Elongin-C | polymer | 96 | 10843.4 | 4 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 3 | C, L (C, L) | von Hippel-Lindau disease tumor suppressor | polymer | 176 | 20530.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | F, I (F, I) | von Hippel-Lindau disease tumor suppressor | polymer | 176 | 20514.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 5 | M, N, O, P (W, X, Y, Z) | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE | polymer | 5 | 491.6 | 4 | synthetic construct | ||
| 6 | Q, Z (B, K) | trifluoroacetic acid | non-polymer | 114.0 | 2 | Chemie (TFA) | |||
| 7 | R (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | S, Y (C, K) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | T, U, V (C, F, H) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 10 | AA, W, X (L, H, I) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 11 | BA, CA, DA, EA, FA... (A, B, C, D, E...) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
C, L: 54 - 213 (UniProt: P40337)
F, I: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | initiating methionine |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Asn 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Tyr 49 | - | expression tag |
| Phe 50 | - | expression tag |
| Gln 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | initiating methionine |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Asn 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Tyr 49 | - | expression tag |
| Phe 50 | - | expression tag |
| Gln 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 174422.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 869.8 | |
| All* | Total formula weight | 175292.6 |
