9B37
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutamate receptor ionotropic, kainate 2 | polymer | 912 | 102976.6 | 4 | UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway rat) | GluK2,Glutamate receptor 6,GluR-6,GluR6 |
2 | E, F | Concanavalin A | polymer | 237 | 25622.4 | 2 | UniProt (C0HJY1) Pfam (PF00139) In PDB | Canavalia ensiformis (jack bean) | ConV |
3 | b, e, G, g, J... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 15 | In PDB GlyTouCan (G42666HT) | |||
4 | d, H, Y | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
5 | I, W | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 2 | In PDB GlyTouCan (G89993FE) | |||
6 | N, O | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 2 | In PDB GlyTouCan (G28663KH) | |||
7 | P | Cyclic 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose | branched | 1114.0 | 1 | In PDB | |||
8 | f, S | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
9 | a | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G31886NL) | |||
10 | c | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1317.2 | 1 | In PDB GlyTouCan (G39213VZ) | |||
11 | A, D, B, C | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 4 | Chemie (2J9) | |||
12 | C, A, D, B | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
13 | C, D, A, B | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 14 | Chemie (POV) | |||
14 | C, A, B | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) | |||
15 | C, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
16 | E, F | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
17 | E, F | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 908 (UniProt: P42260)
E, F: 1 - 237 (UniProt: C0HJY1)
PDB | External Database | Details |
---|---|---|
Val 567 | Ile 567 | conflict |
Cys 571 | Tyr 571 | conflict |
Leu 909 | - | expression tag |
Val 910 | - | expression tag |
Pro 911 | - | expression tag |
Arg 912 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 58 | Gly 58 | conflict |
Ala 70 | Gly 70 | conflict |
Met 129 | Val 129 | conflict |
Glu 192 | Asp 192 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 463151.1 | |
Branched | Number of molecules | 27 |
Total formula weight | 18313.9 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 15945.3 | |
All* | Total formula weight | 497410.3 |