8ZUI

Binary cluster of TNF-TNFR1 ectodomain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, G, H... (A, B, C, G, H...)	Tumor necrosis factor	polymer	170	18855.3	6	UniProt (P01375) Pfam (PF00229)	Homo sapiens (human)	Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a
2	D, E, F, J, K... (D, E, F, J, K...)	Tumor necrosis factor receptor superfamily member 1A, membrane form	polymer	198	22190.9	6	UniProt (P19438) Pfam (PF00020)	Homo sapiens (human)

Sequence modifications

A, B, C, G, H, I: 77 - 233 (UniProt: P01375)

PDB	External Database	Details
Ala 74	-	expression tag
Asp 75	-	expression tag
Pro 76	-	expression tag
Glu 234	-	expression tag
Phe 235	-	expression tag
Arg 236	-	expression tag
Ser 237	-	expression tag
Gly 238	-	expression tag
Arg 239	-	expression tag
Leu 240	-	expression tag
Val 241	-	expression tag
Pro 242	-	expression tag
Arg 243	-	expression tag

D, E, F, J, K, L: 30 - 211 (UniProt: P19438)

PDB	External Database	Details
Ala 27	-	expression tag
Asp 28	-	expression tag
Pro 29	-	expression tag
Gly 212	-	expression tag
Gly 213	-	expression tag
Gly 214	-	expression tag
Gly 215	-	expression tag
Ser 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	246277.5
All*	Total formula weight	246277.5

*Water molecules are not included.