8ZUI

Binary cluster of TNF-TNFR1 ectodomain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005031	molecular_function	tumor necrosis factor receptor activity
D	0006693	biological_process	prostaglandin metabolic process
D	0006954	biological_process	inflammatory response
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
E	0005031	molecular_function	tumor necrosis factor receptor activity
E	0006693	biological_process	prostaglandin metabolic process
E	0006954	biological_process	inflammatory response
E	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0005031	molecular_function	tumor necrosis factor receptor activity
F	0006693	biological_process	prostaglandin metabolic process
F	0006954	biological_process	inflammatory response
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
G	0005164	molecular_function	tumor necrosis factor receptor binding
G	0006955	biological_process	immune response
G	0016020	cellular_component	membrane
H	0005164	molecular_function	tumor necrosis factor receptor binding
H	0006955	biological_process	immune response
H	0016020	cellular_component	membrane
I	0005164	molecular_function	tumor necrosis factor receptor binding
I	0006955	biological_process	immune response
I	0016020	cellular_component	membrane
J	0005031	molecular_function	tumor necrosis factor receptor activity
J	0006693	biological_process	prostaglandin metabolic process
J	0006954	biological_process	inflammatory response
J	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
K	0005031	molecular_function	tumor necrosis factor receptor activity
K	0006693	biological_process	prostaglandin metabolic process
K	0006954	biological_process	inflammatory response
K	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
L	0005031	molecular_function	tumor necrosis factor receptor activity
L	0006693	biological_process	prostaglandin metabolic process
L	0006954	biological_process	inflammatory response
L	0033209	biological_process	tumor necrosis factor-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF

Chain	Residue	Details
A	LEU124-PHE140

---

site_id	PS00652
Number of Residues	38
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqnnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC

Chain	Residue	Details
D	CYS44-CYS81
D	CYS84-CYS125
D	CYS125-CYS166

---

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtChaGFflrene..C

Chain	Residue	Details
D	CYS166-CYS179

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	234
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	252
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	240
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	18
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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