8YJF
Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and an H2A-H2B dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | FACT complex subunit SPT16 | polymer | 350 | 40250.7 | 1 | UniProt (Q9Y5B9) Pfam (PF08512) Pfam (PF21091) In PDB | Homo sapiens (human) | Chromatin-specific transcription elongation factor 140 kDa subunit,FACT 140 kDa subunit,FACTp140,Facilitates chromatin transcription complex subunit SPT16,hSPT16 |
| 2 | B | DNA replication licensing factor MCM2 | polymer | 93 | 10787.6 | 1 | UniProt (P49736) Pfam (PF12619) In PDB | Homo sapiens (human) | Minichromosome maintenance protein 2 homolog,Nuclear protein BM28 |
| 3 | C, E | Histone H3.1 | polymer | 81 | 9379.1 | 2 | UniProt (P68431) Pfam (PF00125) In PDB | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 4 | D, F | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (human) | |
| 5 | G | Histone H2B type 2-E | polymer | 126 | 13951.2 | 1 | UniProt (Q16778) Pfam (PF00125) In PDB | Homo sapiens (human) | Histone H2B-GL105,Histone H2B.q,H2B/q |
| 6 | H | Histone H2A type 1-D | polymer | 136 | 14838.4 | 1 | UniProt (P20671) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (human) | Histone H2A.3,Histone H2A/g |
Sequence modifications
A: 644 - 988 (UniProt: Q9Y5B9)
B: 63 - 154 (UniProt: P49736)
C, E: 56 - 135 (UniProt: P68431)
H: 1 - 129 (UniProt: P20671)
| PDB | External Database | Details |
|---|---|---|
| Gly 639 | - | expression tag |
| Pro 640 | - | expression tag |
| Leu 641 | - | expression tag |
| Gly 642 | - | expression tag |
| Ser 643 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 62 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 55 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| Val -5 | - | expression tag |
| Met -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 121374.9 | |
| All* | Total formula weight | 121374.9 |
