8XWP
Cryo-EM structure of ET-1 bound ETBR-DNGI complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Endothelin receptor type B | polymer | 346 | 38808.3 | 1 | UniProt (P24530) In PDB | Homo sapiens (human) | ET-B,ET-BR,Endothelin receptor non-selective type |
2 | L | Endothelin-1 | polymer | 21 | 2498.0 | 1 | UniProt (P05305) In PDB | Homo sapiens (human) | Preproendothelin-1,PPET1 |
3 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
5 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) In PDB | Homo sapiens (human) | G gamma-I |
6 | D | SCFV16 | polymer | 277 | 29398.9 | 1 | Mus musculus |
Sequence modifications
R: 66 - 407 (UniProt: P24530)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Pro 62 | - | expression tag |
Gly 63 | - | expression tag |
Gly 64 | - | expression tag |
Gly 65 | - | expression tag |
Tyr 124 | Arg 124 | conflict |
Ala 396 | Cys 396 | conflict |
Ala 400 | Cys 400 | conflict |
Ala 405 | Cys 405 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 156651.4 | |
All* | Total formula weight | 156651.4 |