8XRM
RNA polymerase II elongation complex with DSIF, SPT6, and ELOF1 transcribing genomic DNA extracted from human nuclei
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed RNA polymerase II subunit RPB1 | polymer | 1970 | 217420.0 | 1 | UniProt (P24928) Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) | Homo sapiens (human) | RNA polymerase II subunit B1,DNA-directed RNA polymerase II subunit A,DNA-directed RNA polymerase III largest subunit |
| 2 | B (B) | DNA-directed RNA polymerase II subunit RPB2 | polymer | 1174 | 134071.5 | 1 | UniProt (P30876) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) | Homo sapiens (human) | DNA-directed RNA polymerase II 140 kDa polypeptide,DNA-directed RNA polymerase II subunit B |
| 3 | C (C) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 292 | 33630.4 | 1 | UniProt (P19387) Pfam (PF01193) Pfam (PF01000) | Homo sapiens (human) | RNA polymerase II subunit 3,RNA polymerase II subunit B3 |
| 4 | D (D) | DNA-directed RNA polymerase II subunit RPB4 | polymer | 142 | 16331.3 | 1 | UniProt (O15514) Pfam (PF03874) | Homo sapiens (human) | RNA polymerase II subunit B4 |
| 5 | E (E) | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | polymer | 210 | 24584.2 | 1 | UniProt (P19388) Pfam (PF03871) Pfam (PF01191) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC1 |
| 6 | F (F) | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14491.0 | 1 | UniProt (P61218) Pfam (PF01192) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC2 |
| 7 | G (G) | DNA-directed RNA polymerase II subunit RPB7 | polymer | 172 | 19314.3 | 1 | UniProt (P62487) Pfam (PF03876) Pfam (PF00575) | Homo sapiens (human) | RNA polymerase II subunit B7 |
| 8 | H (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (P52434) Pfam (PF03870) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC3 |
| 9 | I (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P36954) Pfam (PF02150) Pfam (PF01096) | Homo sapiens (human) | RNA polymerase II subunit B9 |
| 10 | J (J) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (P62875) Pfam (PF01194) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC5 |
| 11 | K (K) | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 117 | 13310.3 | 1 | UniProt (P52435) Pfam (PF13656) | Homo sapiens (human) | RNA polymerase II subunit B11-a,RPB11a |
| 12 | L (L) | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | polymer | 58 | 7018.2 | 1 | UniProt (P53803) Pfam (PF03604) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC4 |
| 13 | M (M) | Transcription elongation factor SPT6 | polymer | 1726 | 199330.7 | 1 | UniProt (Q7KZ85) Pfam (PF14632) Pfam (PF14641) Pfam (PF22706) Pfam (PF14639) Pfam (PF14635) Pfam (PF17674) Pfam (PF00575) Pfam (PF14633) | Homo sapiens (human) | hSPT6,Histone chaperone suppressor of Ty6 |
| 14 | N (N) | DNA | polymer | 44 | 13708.8 | 1 | Homo sapiens (human) | ||
| 15 | O (P) | RNA | polymer | 21 | 6773.2 | 1 | Homo sapiens (human) | ||
| 16 | P (Q) | Transcription elongation factor 1 homolog | polymer | 83 | 9475.9 | 1 | UniProt (P60002) Pfam (PF05129) | Homo sapiens (human) | |
| 17 | Q (T) | DNA | polymer | 44 | 13396.5 | 1 | Homo sapiens (human) | ||
| 18 | R (Y) | Transcription elongation factor SPT4 | polymer | 117 | 13210.2 | 1 | UniProt (P63272) Pfam (PF06093) | Homo sapiens (human) | hSPT4 |
| 19 | S (Z) | Transcription elongation factor SPT5 | polymer | 1087 | 121145.5 | 1 | UniProt (O00267) Pfam (PF11942) Pfam (PF03439) Pfam (PF00467) | Homo sapiens (human) | hSPT5 |
| 20 | AA, BA, CA, DA, T... (J, L, Q, Y, A...) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 21 | V (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
C: 1 - 275 (UniProt: P19387)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 19 |
| Total formula weight | 896570.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 678.4 | |
| All* | Total formula weight | 897249.0 |
