8XRM
RNA polymerase II elongation complex with DSIF, SPT6, and ELOF1 transcribing genomic DNA extracted from human nuclei
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DNDPNDYVEqdDI |
| Chain | Residue | Details |
| C | ASP136-ILE148 |
| site_id | PS00115 |
| Number of Residues | 7 |
| Details | RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA |
| Chain | Residue | Details |
| A | TYR1593-ALA1599 | |
| A | TYR1671-SER1677 | |
| A | TYR1678-SER1684 | |
| A | TYR1685-SER1691 | |
| A | TYR1692-SER1698 | |
| A | TYR1699-SER1705 | |
| A | TYR1706-SER1712 | |
| A | TYR1713-SER1719 | |
| A | TYR1720-SER1726 | |
| A | TYR1727-SER1733 | |
| A | TYR1734-SER1740 | |
| A | TYR1615-SER1621 | |
| A | TYR1741-ASN1747 | |
| A | TYR1748-ASN1754 | |
| A | TYR1755-SER1761 | |
| A | TYR1762-SER1768 | |
| A | TYR1769-ASN1775 | |
| A | TYR1776-ASN1782 | |
| A | TYR1783-SER1789 | |
| A | TYR1790-SER1796 | |
| A | TYR1797-SER1803 | |
| A | TYR1818-SER1824 | |
| A | TYR1622-SER1628 | |
| A | TYR1825-SER1831 | |
| A | TYR1839-SER1845 | |
| A | TYR1853-LYS1859 | |
| A | TYR1860-LYS1866 | |
| A | TYR1867-LYS1873 | |
| A | TYR1874-THR1880 | |
| A | TYR1888-THR1894 | |
| A | TYR1902-LYS1908 | |
| A | TYR1909-THR1915 | |
| A | TYR1916-LYS1922 | |
| A | TYR1629-ASN1635 | |
| A | TYR1923-THR1929 | |
| A | TYR1930-LYS1936 | |
| A | TYR1947-THR1953 | |
| A | TYR1636-SER1642 | |
| A | TYR1643-SER1649 | |
| A | TYR1650-SER1656 | |
| A | TYR1657-SER1663 | |
| A | TYR1664-SER1670 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH |
| Chain | Residue | Details |
| I | TYR112-HIS118 |
| site_id | PS00446 |
| Number of Residues | 41 |
| Details | RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP |
| Chain | Residue | Details |
| C | ASN32-PRO72 |
| site_id | PS00466 |
| Number of Residues | 38 |
| Details | ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW |
| Chain | Residue | Details |
| I | CYS86-TRP123 |
| site_id | PS01030 |
| Number of Residues | 27 |
| Details | RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC |
| Chain | Residue | Details |
| I | PHE16-CYS42 |
| site_id | PS01110 |
| Number of Residues | 14 |
| Details | RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE |
| Chain | Residue | Details |
| E | HIS142-GLU155 |
| site_id | PS01111 |
| Number of Residues | 15 |
| Details | RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ |
| Chain | Residue | Details |
| F | THR58-GLN72 |
| site_id | PS01112 |
| Number of Residues | 10 |
| Details | RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG |
| Chain | Residue | Details |
| J | ILE2-GLY11 |
| site_id | PS01154 |
| Number of Residues | 32 |
| Details | RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP |
| Chain | Residue | Details |
| K | ILE35-PRO66 |
| site_id | PS01166 |
| Number of Residues | 13 |
| Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT |
| Chain | Residue | Details |
| B | GLY932-THR944 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C4-type => ECO:0000255 |
| Chain | Residue | Details |
| I | CYS17-CYS42 | |
| C | CYS90 | |
| C | CYS94 | |
| C | CYS97 | |
| A | ASP499 | |
| A | ARG1416 | |
| A | ARG1421 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | ZN_FING: TFIIS-type => ECO:0000255|PROSITE-ProRule:PRU00472 |
| Chain | Residue | Details |
| I | GLU82-THR124 | |
| A | ASP495 | |
| B | ASP792 | |
| Y | CYS33 | |
| Y | CYS36 | |
| A | CYS111 | |
| A | CYS114 | |
| A | CYS154 | |
| A | CYS184 | |
| A | ASN493 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10145, ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6 |
| Chain | Residue | Details |
| I | CYS17 | |
| I | CYS20 | |
| I | CYS39 | |
| I | CYS42 | |
| B | LYS942 | |
| B | ARG1078 | |
| B | ARG1085 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6 |
| Chain | Residue | Details |
| I | CYS86 | |
| I | CYS89 | |
| I | CYS114 | |
| I | CYS119 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| I | MET1 | |
| Z | SER789 | |
| Z | SER804 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| B | LYS1052 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O55201 |
| Chain | Residue | Details |
| Z | LYS718 | |
| M | LYS1676 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CDK9 => ECO:0000269|PubMed:10757782 |
| Chain | Residue | Details |
| Z | THR775 | |
| Z | THR784 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| Z | THR791 | |
| A | THR1933 | |
| Z | THR806 | |
| A | THR1870 | |
| A | THR1877 | |
| A | THR1912 | |
| A | THR1915 | |
| A | THR1919 | |
| A | THR1926 | |
| A | THR1929 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| Z | THR1034 | |
| M | SER1528 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| Z | LYS143 | |
| A | SER1857 | |
| A | SER1861 | |
| A | SER1875 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| M | SER1535 | |
| Z | LYS1037 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| M | THR1539 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| M | THR1697 | |
| A | SER1864 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| M | SER1701 | |
| M | SER1703 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q62383 |
| Chain | Residue | Details |
| M | THR1709 | |
| A | LYS1866 | |
| A | LYS1873 | |
| A | LYS1887 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| M | THR1718 | |
| A | TYR1867 | |
| A | TYR1881 | |
| A | TYR1916 | |
| A | TYR1930 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | TYR1874 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1878 | |
| A | SER1882 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR1885 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08775 |
| Chain | Residue | Details |
| A | THR1894 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER1896 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1899 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER1906 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6-dimethyllysine => ECO:0000250|UniProtKB:P08775 |
| Chain | Residue | Details |
| A | LYS1908 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | TYR1909 | |
| A | TYR1923 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1913 | |
| A | SER1920 | |
| A | SER1927 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER1917 | |
| A | SER1931 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:26566685 |
| Chain | Residue | Details |
| A | LYS1922 | |
| A | LYS1936 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1934 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000269|PubMed:32142649, ECO:0000305|PubMed:32142654 |
| Chain | Residue | Details |
| A | LYS1268 |
