8XCH
SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture (ddRTC) in pre-capping initiation.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, I, Q, Y (A, I, Q, Y) | Replicase polyprotein 1ab | polymer | 942 | 108162.5 | 4 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 | pp1ab,ORF1ab polyprotein |
| 2 | B, BA, D, J, L... (B, D, J, L, R...) | Non-structural protein 8 | polymer | 198 | 21903.0 | 8 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 | nsp8 |
| 3 | AA, C, K, S (C, K, S, a) | Non-structural protein 7 | polymer | 83 | 9248.8 | 4 | UniProt (P0DTC1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 | nsp7 |
| 4 | CA, DA, E, F, M... (E, F, M, N, U...) | Helicase | polymer | 601 | 66930.5 | 8 | UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) | Severe acute respiratory syndrome coronavirus 2 | Hel, Non-structural protein 13, nsp13 |
| 5 | EA, G, O, W (G, O, W, e) | RNA (39-MER) | polymer | 39 | 12688.6 | 4 | synthetic construct | ||
| 6 | FA, H, P, X (H, P, X, f) | RNA (39-MER) | polymer | 39 | 12316.3 | 4 | synthetic construct | ||
| 7 | AB, BB, CB, DB, EB... (U, V, A, Y, E...) | ZINC ION | non-polymer | 65.4 | 32 | Chemie (ZN) | |||
| 8 | LA, PB (E, d) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 9 | IB, RA (Y, I) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 10 | QB (d) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence modifications
A, I, Q, Y: 1 - 932 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| His 933 | - | expression tag |
| His 934 | - | expression tag |
| His 935 | - | expression tag |
| His 936 | - | expression tag |
| His 937 | - | expression tag |
| His 938 | - | expression tag |
| His 939 | - | expression tag |
| His 940 | - | expression tag |
| His 941 | - | expression tag |
| His 942 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 1280333.3 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 3091.1 | |
| All* | Total formula weight | 1283424.4 |
