8XCH

SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture (ddRTC) in pre-capping initiation.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I, Q, Y (A, I, Q, Y)	Replicase polyprotein 1ab	polymer	942	108162.5	4	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2	pp1ab,ORF1ab polyprotein
2	B, BA, D, J, L... (B, D, J, L, R...)	Non-structural protein 8	polymer	198	21903.0	8	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2	nsp8
3	AA, C, K, S (C, K, S, a)	Non-structural protein 7	polymer	83	9248.8	4	UniProt (P0DTC1)	Severe acute respiratory syndrome coronavirus 2	nsp7
4	CA, DA, E, F, M... (E, F, M, N, U...)	Helicase	polymer	601	66930.5	8	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2	Hel, Non-structural protein 13, nsp13
5	EA, G, O, W (G, O, W, e)	RNA (39-MER)	polymer	39	12688.6	4		synthetic construct
6	FA, H, P, X (H, P, X, f)	RNA (39-MER)	polymer	39	12316.3	4		synthetic construct
7	AB, BB, CB, DB, EB... (U, V, A, Y, E...)	ZINC ION	non-polymer		65.4	32	Chemie (ZN)
8	LA, PB (E, d)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
9	IB, RA (Y, I)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
10	QB (d)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)

Sequence modifications

A, I, Q, Y: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
His 933	-	expression tag
His 934	-	expression tag
His 935	-	expression tag
His 936	-	expression tag
His 937	-	expression tag
His 938	-	expression tag
His 939	-	expression tag
His 940	-	expression tag
His 941	-	expression tag
His 942	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	32
	Total formula weight	1280333.3
Non-Polymers*	Number of molecules	37
	Total formula weight	3091.1
All*	Total formula weight	1283424.4

*Water molecules are not included.