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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8XCH

SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture (ddRTC) in pre-capping initiation.

Functional Information from GO Data
ChainGOidnamespacecontents
a0004197molecular_functioncysteine-type endopeptidase activity
a0008242molecular_functionomega peptidase activity
a0016740molecular_functiontransferase activity
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0005524molecular_functionATP binding
A0006351biological_processDNA-templated transcription
A0039694biological_processviral RNA genome replication
b0004197molecular_functioncysteine-type endopeptidase activity
b0008242molecular_functionomega peptidase activity
b0016740molecular_functiontransferase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0008242molecular_functionomega peptidase activity
B0016740molecular_functiontransferase activity
c0004386molecular_functionhelicase activity
c0005524molecular_functionATP binding
c0008270molecular_functionzinc ion binding
C0004197molecular_functioncysteine-type endopeptidase activity
C0008242molecular_functionomega peptidase activity
C0016740molecular_functiontransferase activity
d0004386molecular_functionhelicase activity
d0005524molecular_functionATP binding
d0008270molecular_functionzinc ion binding
D0004197molecular_functioncysteine-type endopeptidase activity
D0008242molecular_functionomega peptidase activity
D0016740molecular_functiontransferase activity
E0004386molecular_functionhelicase activity
E0005524molecular_functionATP binding
E0008270molecular_functionzinc ion binding
F0004386molecular_functionhelicase activity
F0005524molecular_functionATP binding
F0008270molecular_functionzinc ion binding
I0003723molecular_functionRNA binding
I0003968molecular_functionRNA-directed RNA polymerase activity
I0005524molecular_functionATP binding
I0006351biological_processDNA-templated transcription
I0039694biological_processviral RNA genome replication
J0004197molecular_functioncysteine-type endopeptidase activity
J0008242molecular_functionomega peptidase activity
J0016740molecular_functiontransferase activity
K0004197molecular_functioncysteine-type endopeptidase activity
K0008242molecular_functionomega peptidase activity
K0016740molecular_functiontransferase activity
L0004197molecular_functioncysteine-type endopeptidase activity
L0008242molecular_functionomega peptidase activity
L0016740molecular_functiontransferase activity
M0004386molecular_functionhelicase activity
M0005524molecular_functionATP binding
M0008270molecular_functionzinc ion binding
N0004386molecular_functionhelicase activity
N0005524molecular_functionATP binding
N0008270molecular_functionzinc ion binding
Q0003723molecular_functionRNA binding
Q0003968molecular_functionRNA-directed RNA polymerase activity
Q0005524molecular_functionATP binding
Q0006351biological_processDNA-templated transcription
Q0039694biological_processviral RNA genome replication
R0004197molecular_functioncysteine-type endopeptidase activity
R0008242molecular_functionomega peptidase activity
R0016740molecular_functiontransferase activity
S0004197molecular_functioncysteine-type endopeptidase activity
S0008242molecular_functionomega peptidase activity
S0016740molecular_functiontransferase activity
T0004197molecular_functioncysteine-type endopeptidase activity
T0008242molecular_functionomega peptidase activity
T0016740molecular_functiontransferase activity
U0004386molecular_functionhelicase activity
U0005524molecular_functionATP binding
U0008270molecular_functionzinc ion binding
V0004386molecular_functionhelicase activity
V0005524molecular_functionATP binding
V0008270molecular_functionzinc ion binding
Y0003723molecular_functionRNA binding
Y0003968molecular_functionRNA-directed RNA polymerase activity
Y0005524molecular_functionATP binding
Y0006351biological_processDNA-templated transcription
Y0039694biological_processviral RNA genome replication
Z0004197molecular_functioncysteine-type endopeptidase activity
Z0008242molecular_functionomega peptidase activity
Z0016740molecular_functiontransferase activity
Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues12
DetailsLIPOCALIN Lipocalin signature. GTS..KFYGGWHNM
ChainResidueDetails
AGLY590-MET601
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1016
DetailsDomain: {"description":"NiRAN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01292","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsRepeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues392
DetailsDomain: {"description":"Nsp12 Interface","evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues648
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues856
DetailsRegion: {"description":"RdRp Fingers N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsRegion: {"description":"Interaction with RMP Remdesivir","evidences":[{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues152
DetailsRegion: {"description":"RdRp Palm N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues232
DetailsRegion: {"description":"RdRp Fingers C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues540
DetailsRegion: {"description":"RdRp Palm C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues216
DetailsRepeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues160
DetailsRepeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues96
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues56
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues672
DetailsDomain: {"description":"CV ZBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1086
DetailsDomain: {"description":"(+)RNA virus helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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