8XCH
SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture (ddRTC) in pre-capping initiation.
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 12 |
| Details | LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM |
| Chain | Residue | Details |
| A | GLY590-MET601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00986, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ |
| Chain | Residue | Details |
| E | CYS5 | |
| E | CYS55 | |
| E | CYS72 | |
| E | HIS75 | |
| F | CYS5 | |
| F | CYS8 | |
| F | CYS16 | |
| F | CYS19 | |
| F | CYS26 | |
| F | CYS29 | |
| F | HIS33 | |
| E | CYS8 | |
| F | HIS39 | |
| F | CYS50 | |
| F | CYS55 | |
| F | CYS72 | |
| F | HIS75 | |
| M | CYS5 | |
| M | CYS8 | |
| M | CYS16 | |
| M | CYS19 | |
| M | CYS26 | |
| E | CYS16 | |
| M | CYS29 | |
| M | HIS33 | |
| M | HIS39 | |
| M | CYS50 | |
| M | CYS55 | |
| M | CYS72 | |
| M | HIS75 | |
| N | CYS5 | |
| N | CYS8 | |
| N | CYS16 | |
| E | CYS19 | |
| N | CYS19 | |
| N | CYS26 | |
| N | CYS29 | |
| N | HIS33 | |
| N | HIS39 | |
| N | CYS50 | |
| N | CYS55 | |
| N | CYS72 | |
| N | HIS75 | |
| U | CYS5 | |
| E | CYS26 | |
| U | CYS8 | |
| U | CYS16 | |
| U | CYS19 | |
| U | CYS26 | |
| U | CYS29 | |
| U | HIS33 | |
| U | HIS39 | |
| U | CYS50 | |
| U | CYS55 | |
| U | CYS72 | |
| E | CYS29 | |
| U | HIS75 | |
| V | CYS5 | |
| V | CYS8 | |
| V | CYS16 | |
| V | CYS19 | |
| V | CYS26 | |
| V | CYS29 | |
| V | HIS33 | |
| V | HIS39 | |
| V | CYS50 | |
| E | HIS33 | |
| V | CYS55 | |
| V | CYS72 | |
| V | HIS75 | |
| c | CYS5 | |
| c | CYS8 | |
| c | CYS16 | |
| c | CYS19 | |
| c | CYS26 | |
| c | CYS29 | |
| c | HIS33 | |
| E | HIS39 | |
| c | HIS39 | |
| c | CYS50 | |
| c | CYS55 | |
| c | CYS72 | |
| c | HIS75 | |
| d | CYS5 | |
| d | CYS8 | |
| d | CYS16 | |
| d | CYS19 | |
| d | CYS26 | |
| E | CYS50 | |
| d | CYS29 | |
| d | HIS33 | |
| d | HIS39 | |
| d | CYS50 | |
| d | CYS55 | |
| d | CYS72 | |
| d | HIS75 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00990 |
| Chain | Residue | Details |
| E | GLY282 | |
| F | GLY282 | |
| M | GLY282 | |
| N | GLY282 | |
| U | GLY282 | |
| V | GLY282 | |
| c | GLY282 | |
| d | GLY282 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| E | GLN601 | |
| Q | CYS301 | |
| Q | CYS306 | |
| Q | CYS310 | |
| Y | HIS295 | |
| Y | CYS301 | |
| Y | CYS306 | |
| Y | CYS310 | |
| F | GLN601 | |
| M | GLN601 | |
| N | GLN601 | |
| U | GLN601 | |
| V | GLN601 | |
| c | GLN601 | |
| d | GLN601 | |
| Q | HIS295 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ |
| Chain | Residue | Details |
| A | CYS487 | |
| Y | CYS487 | |
| Y | HIS642 | |
| Y | CYS646 | |
| A | HIS642 | |
| A | CYS646 | |
| I | CYS487 | |
| I | HIS642 | |
| I | CYS646 | |
| Q | CYS487 | |
| Q | HIS642 | |
| Q | CYS646 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691 |
| Chain | Residue | Details |
| A | CYS645 | |
| I | CYS645 | |
| Q | CYS645 | |
| Y | CYS645 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN932 | |
| I | GLN932 | |
| Q | GLN932 | |
| Y | GLN932 |
