8WRZ
Cry-EM structure of cannabinoid receptor-beta-arrestin-1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-arrestin-1 | polymer | 393 | 44271.5 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) | Homo sapiens (human) | |
| 2 | B (L) | scfv30 light chain, scfv30 heavy chain | polymer | 268 | 28693.9 | 1 | Phage display vector pTDisp | ||
| 3 | C (R) | Soluble cytochrome b562,Cannabinoid receptor 1 | polymer | 476 | 53577.5 | 1 | UniProt (P0ABE7) UniProt (P21554) Pfam (PF07361) Pfam (PF00001) | Escherichia coli | |
| 4 | D (V) | Vasopressin V2 receptor | polymer | 25 | 2920.7 | 1 | UniProt (P30518) | Homo sapiens (human) | |
| 5 | E (R) | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol | non-polymer | 445.7 | 1 | Chemie (8D0) |
Sequence modifications
L: -22 - 124 (PDB: 8WRZ)
L: 125 - 245 (PDB: 8WRZ)
R: -43 - 61 (UniProt: P0ABE7)
R: 71 - 432 (UniProt: P21554)
L: 125 - 245 (PDB: 8WRZ)
R: -43 - 61 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp -37 | Met 29 | engineered mutation |
| Ile 58 | His 124 | engineered mutation |
| Leu 62 | - | linker |
| Leu 63 | - | linker |
| Glu 64 | - | linker |
| Val 65 | - | linker |
| Leu 66 | - | linker |
| Phe 67 | - | linker |
| Gln 68 | - | linker |
| Gly 69 | - | linker |
| Pro 70 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ile 210 | Thr 210 | engineered mutation |
| Lys 273 | Glu 273 | engineered mutation |
| Val 283 | Thr 283 | engineered mutation |
| Glu 340 | Arg 340 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129463.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 445.7 | |
| All* | Total formula weight | 129909.3 |
