8W50
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | DNA topoisomerase 2-alpha | polymer | 806 | 92917.8 | 4 | UniProt (P11388) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) In PDB | Homo sapiens (human) | DNA topoisomerase II,alpha isozyme |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
3 | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 429 - 1188 (UniProt: P11388)
PDB | External Database | Details |
---|---|---|
Met 403 | - | expression tag |
Ala 404 | - | expression tag |
Ser 405 | - | expression tag |
Trp 406 | - | expression tag |
Ser 407 | - | expression tag |
His 408 | - | expression tag |
Pro 409 | - | expression tag |
Gln 410 | - | expression tag |
Phe 411 | - | expression tag |
Glu 412 | - | expression tag |
Lys 413 | - | expression tag |
Gly 414 | - | expression tag |
Ala 415 | - | expression tag |
Asp 416 | - | expression tag |
Asp 417 | - | expression tag |
Asp 418 | - | expression tag |
Asp 419 | - | expression tag |
Lys 420 | - | expression tag |
Val 421 | - | expression tag |
Pro 422 | - | expression tag |
Asp 423 | - | expression tag |
Pro 424 | - | expression tag |
Thr 425 | - | expression tag |
Ser 426 | - | expression tag |
Val 427 | - | expression tag |
Asp 428 | - | expression tag |
Gly 1189 | - | expression tag |
Ala 1190 | - | expression tag |
Pro 1191 | - | expression tag |
Gly 1192 | - | expression tag |
Phe 1193 | - | expression tag |
Ser 1194 | - | expression tag |
Ser 1195 | - | expression tag |
Ile 1196 | - | expression tag |
Ser 1197 | - | expression tag |
Ala 1198 | - | expression tag |
His 1199 | - | expression tag |
His 1200 | - | expression tag |
His 1201 | - | expression tag |
His 1202 | - | expression tag |
His 1203 | - | expression tag |
His 1204 | - | expression tag |
His 1205 | - | expression tag |
His 1206 | - | expression tag |
His 1207 | - | expression tag |
His 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 371671.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 288.2 | |
All* | Total formula weight | 371959.2 |