8W50
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DNA topoisomerase 2-alpha | polymer | 806 | 92917.8 | 4 | UniProt (P11388) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) | Homo sapiens (human) | DNA topoisomerase II,alpha isozyme |
| 2 | E, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 429 - 1188 (UniProt: P11388)
| PDB | External Database | Details |
|---|---|---|
| Met 403 | - | expression tag |
| Ala 404 | - | expression tag |
| Ser 405 | - | expression tag |
| Trp 406 | - | expression tag |
| Ser 407 | - | expression tag |
| His 408 | - | expression tag |
| Pro 409 | - | expression tag |
| Gln 410 | - | expression tag |
| Phe 411 | - | expression tag |
| Glu 412 | - | expression tag |
| Lys 413 | - | expression tag |
| Gly 414 | - | expression tag |
| Ala 415 | - | expression tag |
| Asp 416 | - | expression tag |
| Asp 417 | - | expression tag |
| Asp 418 | - | expression tag |
| Asp 419 | - | expression tag |
| Lys 420 | - | expression tag |
| Val 421 | - | expression tag |
| Pro 422 | - | expression tag |
| Asp 423 | - | expression tag |
| Pro 424 | - | expression tag |
| Thr 425 | - | expression tag |
| Ser 426 | - | expression tag |
| Val 427 | - | expression tag |
| Asp 428 | - | expression tag |
| Gly 1189 | - | expression tag |
| Ala 1190 | - | expression tag |
| Pro 1191 | - | expression tag |
| Gly 1192 | - | expression tag |
| Phe 1193 | - | expression tag |
| Ser 1194 | - | expression tag |
| Ser 1195 | - | expression tag |
| Ile 1196 | - | expression tag |
| Ser 1197 | - | expression tag |
| Ala 1198 | - | expression tag |
| His 1199 | - | expression tag |
| His 1200 | - | expression tag |
| His 1201 | - | expression tag |
| His 1202 | - | expression tag |
| His 1203 | - | expression tag |
| His 1204 | - | expression tag |
| His 1205 | - | expression tag |
| His 1206 | - | expression tag |
| His 1207 | - | expression tag |
| His 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 371671.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 371959.2 |
