8VQE

Homodimeric structure of HER2 S310F extracellular region

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor tyrosine-protein kinase erbB-2/hIgG1 Fc domain fusion	polymer	894	99277.6	2	UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (human)	Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2
2	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)

Sequence modifications

A, B: 23 - 652 (UniProt: P04626)

PDB	External Database	Details
Phe 310	Ser 310	engineered mutation

A, B: 653 - 916 (PDB: 8VQE)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	198555.3
Branched	Number of molecules	2
	Total formula weight	848.8
All*	Total formula weight	199404.1

*Water molecules are not included.