8VM2

Crystal Structure of NRAS Q61K bound to GTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	GTPase NRas	polymer	190	21772.7	3	UniProt (P01111) Pfam (PF00071)	Homo sapiens (human)	Transforming protein N-Ras
2	D, F, H, J, K (A, B, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	5	Chemie (GTP)
3	E, I, L (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	G, M (A, C)	UNKNOWN ATOM OR ION	non-polymer		18.0	2	Chemie (UNX)
5	N, O, P (A, B, C)	water	water		18.0	411	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 172 (UniProt: P01111)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Lys 61	Gln 61	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	65318.0
Non-Polymers*	Number of molecules	10
	Total formula weight	2724.8
All*	Total formula weight	68042.8

*Water molecules are not included.