8VM2

Crystal Structure of NRAS Q61K bound to GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0044877	molecular_function	protein-containing complex binding
A	0046579	biological_process	positive regulation of Ras protein signal transduction
A	0070062	cellular_component	extracellular exosome
A	0070821	cellular_component	tertiary granule membrane
B	0000139	cellular_component	Golgi membrane
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007265	biological_process	Ras protein signal transduction
B	0008284	biological_process	positive regulation of cell population proliferation
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0044877	molecular_function	protein-containing complex binding
B	0046579	biological_process	positive regulation of Ras protein signal transduction
B	0070062	cellular_component	extracellular exosome
B	0070821	cellular_component	tertiary granule membrane
C	0000139	cellular_component	Golgi membrane
C	0000164	cellular_component	protein phosphatase type 1 complex
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007265	biological_process	Ras protein signal transduction
C	0008284	biological_process	positive regulation of cell population proliferation
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0044877	molecular_function	protein-containing complex binding
C	0046579	biological_process	positive regulation of Ras protein signal transduction
C	0070062	cellular_component	extracellular exosome
C	0070821	cellular_component	tertiary granule membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the human NRAS GTPase bound with GDP.","authors":["Nedyalkova L.","Tong Y.","Tempel W.","Shen L.","Loppnau P.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Bochkarev A.","Park H."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30712867","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---