8VM2

Crystal Structure of NRAS Q61K bound to GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0070821	cellular_component	tertiary granule membrane
B	0000139	cellular_component	Golgi membrane
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007265	biological_process	Ras protein signal transduction
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0044877	molecular_function	protein-containing complex binding
B	0070062	cellular_component	extracellular exosome
B	0070821	cellular_component	tertiary granule membrane
C	0000139	cellular_component	Golgi membrane
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007265	biological_process	Ras protein signal transduction
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0044877	molecular_function	protein-containing complex binding
C	0070062	cellular_component	extracellular exosome
C	0070821	cellular_component	tertiary granule membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|Ref.29

Chain	Residue	Details
A	GLY10
A	VAL29
A	ASN116
B	GLY10
B	VAL29
B	ASN116
C	GLY10
C	VAL29
C	ASN116

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	ASP57
B	ASP57
C	ASP57

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by STK19 => ECO:0000269|PubMed:30712867

Chain	Residue	Details
A	SER89
B	SER89
C	SER89

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
A	THR35
B	THR35
C	THR35

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site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762

Chain	Residue	Details
A	LYS170
B	LYS170
C	LYS170

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