8VLB
Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18712.3 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 2 | B (B) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (C) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 4 | D (D) | Cysteine dioxygenase type 1 | polymer | 201 | 23061.0 | 1 | UniProt (Q16878) Pfam (PF05995) | Homo sapiens (human) | Cysteine dioxygenase type I,CDO,CDO-I |
| 5 | E (A) | N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide | non-polymer | 472.6 | 1 | Chemie (3JF) | |||
| 6 | F (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 7 | G (D) | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 8 | H, I (A, C) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 54 - 213 (UniProt: P40337)
D: 1 - 200 (UniProt: Q16878)
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Pro 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65764.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 720.6 | |
| All* | Total formula weight | 66485.1 |
