8VC0

HIV-1 CA crosslinked pentamer in complex with GS-CA1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Capsid protein p24	polymer	231	25476.3	10	UniProt (P12497) Pfam (PF19317)	Human immunodeficiency virus 1	CA
2	K, L, M, N, O... (A, B, C, D, E...)	N-[(1S)-1-{(3M)-3-{4-chloro-3-[(cyclopropanesulfonyl)amino]-1-(2,2-difluoroethyl)-1H-indazol-7-yl}-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide	non-polymer		958.3	10	Chemie (A1AAO)

Sequence modifications

A, B, C, D, E, F, G, H, I, J: 1 - 231 (UniProt: P12497)

PDB	External Database	Details
Cys 21	Asn 153	engineered mutation
Cys 22	Ala 154	engineered mutation
Ala 184	Trp 316	engineered mutation
Ala 185	Met 317	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	254762.8
Non-Polymers*	Number of molecules	10
	Total formula weight	9583.4
All*	Total formula weight	264346.2

*Water molecules are not included.