8V6N

Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily V member 3	polymer	808	92680.0	4	UniProt (Q8NET8) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)
2	AA, DA, E, EA, FA... (C, A, D, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	20	Chemie (POV)
3	F, GA, Q, Y (A, D, B, C)	ARACHIDONIC ACID	non-polymer		304.5	4	Chemie (ACD)
4	BA, CA, I, J, JA... (C, A, D, B)	2-aminoethyl diphenylborinate	non-polymer		225.1	8	Chemie (FZ4)
5	N (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	LA, MA, NA, OA (A, B, C, D)	water	water		18.0	184	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 791 (UniProt: Q8NET8)

PDB	External Database	Details
Leu 792	-	expression tag
Val 793	-	expression tag
Pro 794	-	expression tag
Arg 795	-	expression tag
Gly 796	-	expression tag
Ser 797	-	expression tag
Ala 798	-	expression tag
Ala 799	-	expression tag
Ala 800	-	expression tag
Trp 801	-	expression tag
Ser 802	-	expression tag
His 803	-	expression tag
Pro 804	-	expression tag
Gln 805	-	expression tag
Phe 806	-	expression tag
Glu 807	-	expression tag
Lys 808	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	370720.1
Non-Polymers*	Number of molecules	33
	Total formula weight	18243.1
All*	Total formula weight	388963.2

*Water molecules are not included.