8USR
IL17A homodimer complexed to Compound 23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Interleukin-17A | polymer | 127 | 14537.3 | 4 | UniProt (Q16552) Pfam (PF06083) In PDB | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | A, D | ~{N}-[(2~{S})-1-[[(1~{S})-1-(8~{a}~{H}-imidazo[1,2-a]pyrimidin-2-yl)ethyl]amino]-1-oxidanylidene-4-phenyl-butan-2-yl]-4,5-bis(chloranyl)-1~{H}-pyrrole-2-carboxamide | non-polymer | 485.4 | 4 | Chemie (XCE) | |||
| 3 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Met 32 | - | expression tag |
| Ala 33 | - | expression tag |
| Ser 129 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58149.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1941.5 | |
| All* | Total formula weight | 60090.8 |
