8URJ
Cryo-EM structure of the HIV-1 nuclear export complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Exportin-1 | polymer | 1062 | 122268.0 | 2 | UniProt (O14980) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Homo sapiens (human) | Chromosome Maintenance 1 |
| 2 | B (B) | Rev HIV-1 | polymer | 92 | 10687.2 | 1 | Human immunodeficiency virus 1 | ||
| 3 | D, F (D, H) | GTP-binding nuclear protein Ran | polymer | 181 | 20722.1 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 4 | E (E) | Rev HIV-1 | polymer | 92 | 10644.1 | 1 | Pfam (PF00424) UniProt (by SIFTS) (P69718) | Human immunodeficiency virus 1 | |
| 5 | G (G) | HIV-1 RRE | polymer | 355 | 114996.1 | 1 | GenBank (328658) | Human immunodeficiency virus 1 |
Sequence modifications
A, C: 1 - 1056 (UniProt: O14980)
D, H: 3 - 179 (UniProt: P62826)
G: 1 - 540 (GenBank: 328658)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Met -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Met 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Leu 69 | Gln 69 | conflict |
| PDB | External Database | Details |
|---|---|---|
| A 447 | G 7960 | engineered mutation |
| A 454 | G 7967 | engineered mutation |
| G 499 | A 8012 | conflict |
| A 500 | U 8013 | conflict |
| A 501 | U 8014 | conflict |
| U 503 | G 8016 | conflict |
| C 504 | G 8017 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 422307.5 | |
| All* | Total formula weight | 422307.5 |
