Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8URJ

Cryo-EM structure of the HIV-1 nuclear export complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000776	cellular_component	kinetochore
A	0003723	molecular_function	RNA binding
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005642	cellular_component	annulate lamellae
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006406	biological_process	mRNA export from nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0009410	biological_process	response to xenobiotic stimulus
A	0010824	biological_process	regulation of centrosome duplication
A	0015030	cellular_component	Cajal body
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0031965	cellular_component	nuclear membrane
A	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032991	cellular_component	protein-containing complex
A	0034504	biological_process	protein localization to nucleus
A	0042176	biological_process	regulation of protein catabolic process
A	0042254	biological_process	ribosome biogenesis
A	0046825	biological_process	regulation of protein export from nucleus
A	0051028	biological_process	mRNA transport
A	0071401	biological_process	cellular response to triglyceride
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1902075	biological_process	cellular response to salt
A	1990904	cellular_component	ribonucleoprotein complex
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000776	cellular_component	kinetochore
C	0003723	molecular_function	RNA binding
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005642	cellular_component	annulate lamellae
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006406	biological_process	mRNA export from nucleus
C	0006611	biological_process	protein export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0009410	biological_process	response to xenobiotic stimulus
C	0010824	biological_process	regulation of centrosome duplication
C	0015030	cellular_component	Cajal body
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0019904	molecular_function	protein domain specific binding
C	0031965	cellular_component	nuclear membrane
C	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032991	cellular_component	protein-containing complex
C	0034504	biological_process	protein localization to nucleus
C	0042176	biological_process	regulation of protein catabolic process
C	0042254	biological_process	ribosome biogenesis
C	0046825	biological_process	regulation of protein export from nucleus
C	0051028	biological_process	mRNA transport
C	0071401	biological_process	cellular response to triglyceride
C	0140297	molecular_function	DNA-binding transcription factor binding
C	1902075	biological_process	cellular response to salt
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host CK2 => ECO:0000255\|HAMAP-Rule:MF_04077

Chain	Residue	Details
E	SER5
E	SER8

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10078529, ECO:0000269\|PubMed:10353245, ECO:0000269\|PubMed:10367892, ECO:0000269\|PubMed:11832950, ECO:0000269\|PubMed:19389996, ECO:0000269\|PubMed:24449914, ECO:0000269\|PubMed:24915079, ECO:0000269\|PubMed:26272610, ECO:0000269\|PubMed:26349033, ECO:0000269\|PubMed:28282025, ECO:0000269\|PubMed:7885480, ECO:0007744\|PDB:1IBR, ECO:0007744\|PDB:1K5D, ECO:0007744\|PDB:1QBK, ECO:0007744\|PDB:1RRP, ECO:0007744\|PDB:3GJX, ECO:0007744\|PDB:3NBY, ECO:0007744\|PDB:3NBZ, ECO:0007744\|PDB:3NC0, ECO:0007744\|PDB:3NC1, ECO:0007744\|PDB:3ZJY, ECO:0007744\|PDB:4C0Q, ECO:0007744\|PDB:4OL0, ECO:0007744\|PDB:5CLL, ECO:0007744\|PDB:5CLQ, ECO:0007744\|PDB:5DH9, ECO:0007744\|PDB:5DHA, ECO:0007744\|PDB:5DHF, ECO:0007744\|PDB:5DI9, ECO:0007744\|PDB:5DIF, ECO:0007744\|PDB:5DIS, ECO:0007744\|PDB:5DLQ, ECO:0007744\|PDB:5JLJ, ECO:0007744\|PDB:5UWH, ECO:0007744\|PDB:5UWI, ECO:0007744\|PDB:5UWJ, ECO:0007744\|PDB:5UWO, ECO:0007744\|PDB:5UWP, ECO:0007744\|PDB:5UWQ, ECO:0007744\|PDB:5UWR, ECO:0007744\|PDB:5UWS, ECO:0007744\|PDB:5UWT, ECO:0007744\|PDB:5UWU, ECO:0007744\|PDB:5UWW

Chain	Residue	Details
D	GLU36
H	GLU36
C	LYS446
C	LYS693

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10078529, ECO:0000269\|PubMed:10353245, ECO:0000269\|PubMed:10367892, ECO:0000269\|PubMed:11832950, ECO:0000269\|PubMed:18611384, ECO:0000269\|PubMed:19389996, ECO:0000269\|PubMed:19505478, ECO:0000269\|PubMed:24449914, ECO:0000269\|PubMed:24915079, ECO:0000269\|PubMed:26272610, ECO:0000269\|PubMed:26349033, ECO:0000269\|PubMed:28282025, ECO:0000269\|PubMed:7885480, ECO:0007744\|PDB:1IBR, ECO:0007744\|PDB:1K5D, ECO:0007744\|PDB:1QBK, ECO:0007744\|PDB:1RRP, ECO:0007744\|PDB:3GJX, ECO:0007744\|PDB:3NBY, ECO:0007744\|PDB:3NBZ, ECO:0007744\|PDB:3NC0, ECO:0007744\|PDB:3NC1, ECO:0007744\|PDB:3ZJY, ECO:0007744\|PDB:4C0Q, ECO:0007744\|PDB:4OL0, ECO:0007744\|PDB:5DH9, ECO:0007744\|PDB:5DHA, ECO:0007744\|PDB:5DHF, ECO:0007744\|PDB:5DI9, ECO:0007744\|PDB:5DIF, ECO:0007744\|PDB:5DIS, ECO:0007744\|PDB:5DLQ, ECO:0007744\|PDB:5JLJ, ECO:0007744\|PDB:5UWH, ECO:0007744\|PDB:5UWI, ECO:0007744\|PDB:5UWJ, ECO:0007744\|PDB:5UWO, ECO:0007744\|PDB:5UWP, ECO:0007744\|PDB:5UWQ, ECO:0007744\|PDB:5UWR, ECO:0007744\|PDB:5UWS, ECO:0007744\|PDB:5UWT, ECO:0007744\|PDB:5UWU, ECO:0007744\|PDB:5UWW

Chain	Residue	Details
D	GLY68
H	GLY68

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10078529, ECO:0000269\|PubMed:10353245, ECO:0000269\|PubMed:10367892, ECO:0000269\|PubMed:11832950, ECO:0000269\|PubMed:18611384, ECO:0000269\|PubMed:19389996, ECO:0000269\|PubMed:19505478, ECO:0000269\|PubMed:24449914, ECO:0000269\|PubMed:24915079, ECO:0000269\|PubMed:26272610, ECO:0000269\|PubMed:26349033, ECO:0000269\|PubMed:28282025, ECO:0000269\|PubMed:7885480, ECO:0007744\|PDB:1IBR, ECO:0007744\|PDB:1K5D, ECO:0007744\|PDB:1QBK, ECO:0007744\|PDB:1RRP, ECO:0007744\|PDB:3CH5, ECO:0007744\|PDB:3GJ0, ECO:0007744\|PDB:3GJ3, ECO:0007744\|PDB:3GJ4, ECO:0007744\|PDB:3GJ5, ECO:0007744\|PDB:3GJ6, ECO:0007744\|PDB:3GJ7, ECO:0007744\|PDB:3GJ8, ECO:0007744\|PDB:3GJX, ECO:0007744\|PDB:3NBY, ECO:0007744\|PDB:3NBZ, ECO:0007744\|PDB:3NC0, ECO:0007744\|PDB:3NC1, ECO:0007744\|PDB:3ZJY, ECO:0007744\|PDB:4C0Q, ECO:0007744\|PDB:4OL0, ECO:0007744\|PDB:5CIQ, ECO:0007744\|PDB:5CIT, ECO:0007744\|PDB:5CIW, ECO:0007744\|PDB:5CJ2, ECO:0007744\|PDB:5CLL, ECO:0007744\|PDB:5DH9, ECO:0007744\|PDB:5DHA, ECO:0007744\|PDB:5DHF, ECO:0007744\|PDB:5DI9, ECO:0007744\|PDB:5DIF, ECO:0007744\|PDB:5DIS, ECO:0007744\|PDB:5DLQ, ECO:0007744\|PDB:5JLJ, ECO:0007744\|PDB:5UWH, ECO:0007744\|PDB:5UWI, ECO:0007744\|PDB:5UWJ, ECO:0007744\|PDB:5UWO, ECO:0007744\|PDB:5UWP, ECO:0007744\|PDB:5UWQ, ECO:0007744\|PDB:5UWR, ECO:0007744\|PDB:5UWS, ECO:0007744\|PDB:5UWT, ECO:0007744\|PDB:5UWU, ECO:0007744\|PDB:5UWW

Chain	Residue	Details
D	ASN122
H	ASN122

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10078529, ECO:0000269\|PubMed:10353245, ECO:0000269\|PubMed:10367892, ECO:0000269\|PubMed:11832950, ECO:0000269\|PubMed:18611384, ECO:0000269\|PubMed:19389996, ECO:0000269\|PubMed:19505478, ECO:0000269\|PubMed:24449914, ECO:0000269\|PubMed:24915079, ECO:0000269\|PubMed:26272610, ECO:0000269\|PubMed:26349033, ECO:0000269\|PubMed:28282025, ECO:0000269\|PubMed:7885480, ECO:0007744\|PDB:1K5G, ECO:0007744\|PDB:3CH5, ECO:0007744\|PDB:3GJ0, ECO:0007744\|PDB:3GJ3, ECO:0007744\|PDB:3GJ4, ECO:0007744\|PDB:3GJ5, ECO:0007744\|PDB:3GJ6, ECO:0007744\|PDB:3GJ7, ECO:0007744\|PDB:3GJ8, ECO:0007744\|PDB:3GJX, ECO:0007744\|PDB:3NBY, ECO:0007744\|PDB:3NBZ, ECO:0007744\|PDB:3NC0, ECO:0007744\|PDB:3NC1, ECO:0007744\|PDB:3ZJY, ECO:0007744\|PDB:4C0Q, ECO:0007744\|PDB:4OL0, ECO:0007744\|PDB:5CIQ, ECO:0007744\|PDB:5CIT, ECO:0007744\|PDB:5CIW, ECO:0007744\|PDB:5CJ2, ECO:0007744\|PDB:5CLL, ECO:0007744\|PDB:5CLQ, ECO:0007744\|PDB:5DH9, ECO:0007744\|PDB:5DHA, ECO:0007744\|PDB:5DHF, ECO:0007744\|PDB:5DI9, ECO:0007744\|PDB:5DIF, ECO:0007744\|PDB:5DIS, ECO:0007744\|PDB:5DLQ, ECO:0007744\|PDB:5JLJ, ECO:0007744\|PDB:5UWH, ECO:0007744\|PDB:5UWI, ECO:0007744\|PDB:5UWJ, ECO:0007744\|PDB:5UWO, ECO:0007744\|PDB:5UWP, ECO:0007744\|PDB:5UWQ, ECO:0007744\|PDB:5UWR, ECO:0007744\|PDB:5UWS, ECO:0007744\|PDB:5UWT, ECO:0007744\|PDB:5UWU, ECO:0007744\|PDB:5UWW

Chain	Residue	Details
D	SER150
H	SER150

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Essential for GTP hydrolysis => ECO:0000269\|PubMed:18591255, ECO:0000269\|PubMed:26272610, ECO:0000269\|PubMed:8636225

Chain	Residue	Details
D	LEU69
H	LEU69

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
D	THR24
H	THR24

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:31075303

Chain	Residue	Details
D	LYS37
H	LYS37

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
D	LYS60
D	LYS99
H	LYS60
H	LYS99

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
D	LYS71
H	LYS71

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:29040603

Chain	Residue	Details
D	LYS134
H	LYS134

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P62827

Chain	Residue	Details
D	LYS159
H	LYS159

site_id	SWS_FT_FI13
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
D	LYS71
H	LYS71

site_id	SWS_FT_FI14
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
D	LYS152
H	LYS152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)