8UM5
X-ray structure of human SHIP1 Ptase-C2 domains covalently bound to TREAT-AD (TAD) compound TAD-58547
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | polymer | 463 | 52877.6 | 1 | UniProt (Q92835) Pfam (PF22669) | Homo sapiens (human) | |
| 2 | B (A) | 5-(1,4-oxazepan-4-yl)-6-propanoylpyridine-2-carbonitrile | non-polymer | 259.3 | 1 | Chemie (X3F) | |||
| 3 | C, D, E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 4 | F (A) | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
A: 396 - 856 (UniProt: Q92835)
| PDB | External Database | Details |
|---|---|---|
| Ser 394 | - | expression tag |
| Met 395 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52877.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 493.7 | |
| All* | Total formula weight | 53371.3 |
