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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8U4O

Structure of CXCL12-bound CXCR4/Gi complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		C-X-C chemokine receptor type 4polymer63271063.61UniProt (P61073)
Pfam (PF12109)
Pfam (PF00001)
UniProt (by SIFTS) (P42212)		Homo sapiens (human)
2B
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer36541591.31UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35038534.11UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
4D
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(J)		Stromal cell-derived factor 1polymer687978.51UniProt (P48061)
Pfam (PF00048)		Homo sapiens (human)hSDF-1,C-X-C motif chemokine 12,Intercrine reduced in hepatomas,hIRH,Pre-B cell growth-stimulating factor,PBSF
6F
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
R: 2 - 352 (UniProt: P61073)
PDBExternal DatabaseDetails
Met -17-initiating methionine
Lys -16-expression tag
Thr -15-expression tag
Ile -14-expression tag
Ile -13-expression tag
Ala -12-expression tag
Leu -11-expression tag
Ser -10-expression tag
Tyr -9-expression tag
Ile -8-expression tag
Phe -7-expression tag
Cys -6-expression tag
Leu -5-expression tag
Val -4-expression tag
Phe -3-expression tag
Ala -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Pro 1-expression tag
Ser 119Asn 119conflict
R: 353 - 614 (PDB: 8U4O)
A: 2 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Met -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Gly -2-expression tag
Gly -1-expression tag
Gly 0-expression tag
Ser 1-expression tag
Cys 47Ser 47conflict
Thr 202Gly 202conflict
Ala 203Gly 203conflict
Ala 245Glu 245conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight167028.6
Non-Polymers*Number of molecules1
Total formula weight386.7
All*Total formula weight167415.2
*Water molecules are not included.

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PDB entries from 2026-05-06

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