8U15
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Protein cereblon | polymer | 373 | 42971.6 | 2 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 2 | B, E (B, E) | DDB1 | polymer | 836 | 93347.1 | 2 | Pfam (PF10433) Pfam (PF03178) UniProt (by SIFTS) (Q16531) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Sal-like protein 4 | polymer | 55 | 6417.5 | 2 | UniProt (Q9UJQ4) Pfam (PF00096) | Homo sapiens (human) | Zinc finger protein 797,Zinc finger protein SALL4 |
| 4 | G, N, O, Q, X... (A, C, D, F) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | H, R (A, D) | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | non-polymer | 449.5 | 2 | Chemie (8W7) | |||
| 6 | I, J, K, L, M... (A, B, C, D, E...) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 7 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
C, F: 379 - 432 (UniProt: Q9UJQ4)
| PDB | External Database | Details |
|---|---|---|
| Ser 378 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 285472.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2444.2 | |
| All* | Total formula weight | 287916.4 |
