8U15

The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003676	molecular_function	nucleic acid binding
B	0005634	cellular_component	nucleus
E	0003676	molecular_function	nucleic acid binding
E	0005634	cellular_component	nucleus

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cky..CskvFgtdsslqiHlrs..H

Chain	Residue	Details
C	CYS384-HIS404
C	CYS412-HIS432

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
B	SER2
D	HIS378
D	TRP380
D	TRP386
D	CYS391
D	CYS394
E	SER2
A	HIS378
A	TRP380
A	TRP386
A	CYS391
A	CYS394
D	CYS323
D	CYS326

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	PHE410-HIS432
F	PHE410-HIS432

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain

Residue

Details

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