8TXY
X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase MARK2 | polymer | 317 | 36722.5 | 2 | UniProt (Q7KZI7) Pfam (PF00069) Pfam (PF00627) | Homo sapiens (human) | ELKL motif kinase 1,EMK-1,MAP/microtubule affinity-regulating kinase 2,PAR1 homolog,PAR1 homolog b,Par-1b,Par1b |
| 2 | C, D, G (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 3 | E, H (A, B) | N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | non-polymer | 416.5 | 2 | Chemie (SJ0) | |||
| 4 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 47 - 363 (UniProt: Q7KZI7)
| PDB | External Database | Details |
|---|---|---|
| Leu 59 | Ile 59 | engineered mutation |
| Val 66 | Lys 66 | engineered mutation |
| Ile 81 | Val 81 | engineered mutation |
| Ile 97 | Leu 97 | engineered mutation |
| Ile 113 | Val 113 | engineered mutation |
| Thr 129 | Met 129 | engineered mutation |
| Lys 133 | Ser 133 | engineered mutation |
| Asn 134 | Gly 134 | engineered mutation |
| Gly 197 | Ser 197 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73445.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1247.4 | |
| All* | Total formula weight | 74692.4 |
