8TS0

Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	8M24 Fab Heavy chain	polymer	236	25327.1	1		Homo sapiens
2	B (L)	8M24 Fab Light chain	polymer	214	23489.1	1		Homo sapiens
3	C (A)	Asialoglycoprotein receptor 1	polymer	169	19740.4	1	UniProt (P07306) Pfam (PF00059)	Homo sapiens (human)
4	D, E, F, G, H... (H, L, A)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	I, J, K (A)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
6	M, N, O (H, L, A)	water	water		18.0	416	Chemie (HOH)

Sequence modifications

A: 154 - 291 (UniProt: P07306)

PDB	External Database	Details
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
Gly 131	-	expression tag
Ser 132	-	expression tag
Gly 133	-	expression tag
Ser 134	-	expression tag
Gly 135	-	expression tag
Leu 136	-	expression tag
Asn 137	-	expression tag
Asp 138	-	expression tag
Ile 139	-	expression tag
Phe 140	-	expression tag
Glu 141	-	expression tag
Ala 142	-	expression tag
Gln 143	-	expression tag
Lys 144	-	expression tag
Ile 145	-	expression tag
Glu 146	-	expression tag
Trp 147	-	expression tag
His 148	-	expression tag
Glu 149	-	expression tag
Ser 150	-	expression tag
Gly 151	-	expression tag
Ser 152	-	expression tag
Gly 153	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	68556.6
Non-Polymers*	Number of molecules	9
	Total formula weight	672.8
All*	Total formula weight	69229.4

*Water molecules are not included.