8TGA

Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (B, A)	Atrial natriuretic peptide receptor 1	polymer	469	52263.7	2	UniProt (P16066) Pfam (PF01094)	Homo sapiens (human)	Atrial natriuretic peptide receptor type A,ANP-A,ANPR-A,NPR-A,Guanylate cyclase A,GC-A
2	B, E (F, L)	REGN5381 Fab light chain	polymer	213	23323.9	2		Mus musculus (mouse)
3	C, F (E, H)	REGN5381 Fab heavy chain	polymer	229	24818.8	2		Mus musculus (mouse)

Sequence modifications

B, A: 1 - 441 (UniProt: P16066)

PDB	External Database	Details
Glu 442	-	expression tag
Gln 443	-	expression tag
Lys 444	-	expression tag
Leu 445	-	expression tag
Ile 446	-	expression tag
Ser 447	-	expression tag
Glu 448	-	expression tag
Glu 449	-	expression tag
Asp 450	-	expression tag
Leu 451	-	expression tag
Gly 452	-	expression tag
Gly 453	-	expression tag
Glu 454	-	expression tag
Gln 455	-	expression tag
Lys 456	-	expression tag
Leu 457	-	expression tag
Ile 458	-	expression tag
Ser 459	-	expression tag
Glu 460	-	expression tag
Glu 461	-	expression tag
Asp 462	-	expression tag
Leu 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag
His 469	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	200812.8
All*	Total formula weight	200812.8

*Water molecules are not included.