8TGA
Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| F | TYR191-HIS197 | |
| E | TYR205-HIS211 |
| site_id | PS00458 |
| Number of Residues | 18 |
| Details | ANF_RECEPTORS Natriuretic peptides receptors signature. GPgCvYaAApVgRftaHW |
| Chain | Residue | Details |
| B | GLY83-TRP100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 880 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY1-GLU441 | |
| A | GLY1-GLU441 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | SER53 | |
| B | GLY85 | |
| B | CYS86 | |
| A | SER53 | |
| A | GLY85 | |
| A | CYS86 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN2 | |
| A | ASN180 | |
| A | ASN306 | |
| A | ASN347 | |
| A | ASN354 | |
| A | ASN395 | |
| B | ASN13 | |
| B | ASN180 | |
| B | ASN306 | |
| B | ASN347 | |
| B | ASN354 | |
| B | ASN395 | |
| A | ASN2 | |
| A | ASN13 |
