8TE1
Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, E, H...) | DNA (cytosine-5)-methyltransferase 3A | polymer | 287 | 32812.8 | 8 | UniProt (Q9Y6K1) Pfam (PF00145) | Homo sapiens (human) | Dnmt3a,Cysteine methyltransferase DNMT3A,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,M.HsaIIIA |
| 2 | I, N, Q, W (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (6419189) PubChem (193) PubChem (164157219) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) | |||
| 3 | J, K, L, M, O... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) PubChem (753) | |||
| 4 | R (C) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) PubChem (875) PubChem (5851) PubChem (78956) PubChem (439655) PubChem (444305) PubChem (447315) | |||
| 5 | AA, BA, CA, DA, EA... (C, E, H, F, D...) | water | water | 18.0 | 600 | Chemie (HOH) |
Sequence modifications
A, B, C, E, H, F, D, G: 628 - 912 (UniProt: Q9Y6K1)
| PDB | External Database | Details |
|---|---|---|
| Gly 626 | - | expression tag |
| Ser 627 | - | expression tag |
| Lys 676 | Arg 676 | engineered mutation |
| His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 262502.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2700.8 | |
| All* | Total formula weight | 265203.0 |
