8TE1
Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, E, H... | DNA (cytosine-5)-methyltransferase 3A | polymer | 287 | 32812.8 | 8 | UniProt (Q9Y6K1) Pfam (PF00145) In PDB | Homo sapiens (human) | Dnmt3a,Cysteine methyltransferase DNMT3A,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,M.HsaIIIA |
2 | A, B, C, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
3 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
4 | C | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
5 | water | water | 18.0 | 600 | Chemie (HOH) |
Sequence modifications
A, B, C, E, H, F, D, G: 628 - 912 (UniProt: Q9Y6K1)
PDB | External Database | Details |
---|---|---|
Gly 626 | - | expression tag |
Ser 627 | - | expression tag |
Lys 676 | Arg 676 | engineered mutation |
His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 262502.2 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 2700.8 | |
All* | Total formula weight | 265203.0 |