8TAS
PRC2 monomer bound to nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Polycomb protein SUZ12 | polymer | 619 | 72266.4 | 1 | UniProt (Q15022) Pfam (PF23320) Pfam (PF09733) | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | B (E) | Histone-lysine N-methyltransferase EZH2 | polymer | 753 | 86175.0 | 1 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | C (G) | Polycomb protein EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 4 | D, L (I, W) | Histone H3.2 | polymer | 136 | 15435.1 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 5 | E (H) | DNA (226-MER) | polymer | 215 | 66539.3 | 1 | synthetic construct | ||
| 6 | F, M (J, X) | Histone H4 | polymer | 106 | 11625.6 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 7 | G, J (R, U) | Histone H2A | polymer | 133 | 14355.7 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) | Xenopus laevis (African clawed frog) | |
| 8 | H, K (S, V) | Histone H2B 1.1 | polymer | 123 | 13655.9 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 9 | I (T) | DNA (226-MER) | polymer | 215 | 65905.9 | 1 | synthetic construct | ||
| 10 | N (O) | Histone-binding protein RBBP4 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 11 | O (Y) | Zinc finger protein AEBP2 | polymer | 303 | 34183.2 | 1 | UniProt (Q6ZN18) Pfam (PF26014) | Homo sapiens (human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 12 | P (E) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
D: 68 - 685 (UniProt: Q15022)
E: 2 - 751 (UniProt: Q15910)
I, W: 0 - 135 (UniProt: P84233)
J, X: 0 - 102 (UniProt: P62799)
R, U: 0 - 129 (UniProt: Q6AZJ8)
S, V: 1 - 122 (UniProt: P02281)
Y: 16 - 309 (UniProt: Q6ZN18)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Ala 14 | Cys 14 | conflict |
| Cys 15 | Trp 15 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 103 | - | expression tag |
| Ser 104 | - | expression tag |
| Gly 105 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -3 | - | expression tag |
| Asn -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Cys 119 | Lys 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Thr 29 | Ser 33 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | - | expression tag |
| Asn 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Thr 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Arg 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Ser 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 533191.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 533576.1 |
