8TAS
PRC2 monomer bound to nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D | Polycomb protein SUZ12 | polymer | 619 | 72266.4 | 1 | UniProt (Q15022) In PDB | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | E | Histone-lysine N-methyltransferase EZH2 | polymer | 753 | 86175.0 | 1 | UniProt (Q15910) In PDB | Homo sapiens (human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | G | Polycomb protein EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) In PDB | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 4 | I, W | Histone H3.2 | polymer | 136 | 15435.1 | 2 | UniProt (P84233) In PDB | Xenopus laevis (African clawed frog) | |
| 5 | H | DNA (226-MER) | polymer | 215 | 66539.3 | 1 | synthetic construct | ||
| 6 | J, X | Histone H4 | polymer | 106 | 11625.6 | 2 | UniProt (P62799) In PDB | Xenopus laevis (African clawed frog) | |
| 7 | R, U | Histone H2A | polymer | 133 | 14355.7 | 2 | UniProt (Q6AZJ8) In PDB | Xenopus laevis (African clawed frog) | |
| 8 | S, V | Histone H2B 1.1 | polymer | 123 | 13655.9 | 2 | UniProt (P02281) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
| 9 | T | DNA (226-MER) | polymer | 215 | 65905.9 | 1 | synthetic construct | ||
| 10 | O | Histone-binding protein RBBP4 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) In PDB | Homo sapiens (human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 11 | Y | Zinc finger protein AEBP2 | polymer | 303 | 34183.2 | 1 | UniProt (Q6ZN18) In PDB | Homo sapiens (human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 12 | E | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
D: 68 - 685 (UniProt: Q15022)
E: 2 - 751 (UniProt: Q15910)
I, W: 0 - 135 (UniProt: P84233)
J, X: 0 - 102 (UniProt: P62799)
R, U: 0 - 129 (UniProt: Q6AZJ8)
S, V: 1 - 122 (UniProt: P02281)
Y: 16 - 309 (UniProt: Q6ZN18)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Ala 14 | Cys 14 | conflict |
| Cys 15 | Trp 15 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 103 | - | expression tag |
| Ser 104 | - | expression tag |
| Gly 105 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -3 | - | expression tag |
| Asn -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Cys 119 | Lys 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Thr 29 | Ser 33 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | - | expression tag |
| Asn 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Thr 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Arg 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Ser 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 533191.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 533576.1 |
