8TAS
PRC2 monomer bound to nucleosome
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 24 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H |
| Chain | Residue | Details |
| Y | CYS55-HIS78 | |
| Y | CYS122-HIS144 | |
| D | CYS450-HIS471 |
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| R | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| J | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| I | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| S | ARG89-GLY111 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| G | LEU206-ILE220 | |
| O | LEU193-ILE207 | |
| O | LEU289-LEU303 | |
| O | LEU333-LEU347 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| I | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| Y | TYR53-HIS78 | |
| S | LYS9 | |
| S | LYS12 | |
| S | LYS17 | |
| V | LYS2 | |
| V | LYS9 | |
| V | LYS12 | |
| V | LYS17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 2; degenerate => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| Y | LYS92-HIS114 | |
| V | SER11 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| Y | PHE120-HIS144 | |
| V | SER109 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| Y | SER182 | |
| X | LYS5 | |
| V | LYS117 | |
| G | LYS284 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| O | SER355 | |
| J | LYS16 | |
| J | LYS44 | |
| J | LYS79 | |
| X | LYS8 | |
| X | LYS16 | |
| X | LYS44 | |
| X | LYS79 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate |
| Chain | Residue | Details |
| O | LYS4 | |
| J | LYS20 | |
| X | LYS12 | |
| X | LYS20 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| J | LYS31 | |
| O | LYS160 | |
| X | LYS31 | |
| X | LYS91 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PAK2 => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| J | SER47 | |
| X | SER47 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| J | TYR51 | |
| J | TYR88 | |
| X | TYR51 | |
| X | TYR88 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| J | LYS59 | |
| W | LYS64 | |
| X | LYS59 | |
| I | LYS27 | |
| I | LYS36 | |
| I | LYS64 | |
| W | LYS18 | |
| W | LYS23 | |
| W | LYS27 | |
| W | LYS36 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| J | LYS77 | |
| X | LYS77 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| J | LYS31 | |
| X | LYS31 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| I | LYS37 | |
| J | LYS91 | |
| X | LYS91 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | TYR41 | |
| W | TYR41 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228 |
| Chain | Residue | Details |
| I | LYS56 | |
| I | LYS79 | |
| W | LYS56 | |
| W | LYS79 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | SER57 | |
| W | SER57 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | THR80 | |
| I | THR107 | |
| W | THR80 | |
| W | THR107 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| I | SER86 | |
| W | SER86 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | LYS115 | |
| W | LYS115 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | LYS122 | |
| W | LYS122 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| I | CYS110 | |
| W | CYS110 |
