8SZK

The cryo-EM structure of PPP2R5A/HIV-1 Vif/CBFb/EloB/EloC complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Elongin-B	polymer	118	13147.8	1	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B	Elongin-C	polymer	96	10843.4	1	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (human)	EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1
3	C	Core-binding factor subunit beta	polymer	201	23644.2	1	UniProt (Q13951) Pfam (PF02312) In PDB	Homo sapiens (human)	CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEA2-beta,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit
4	G	Virion infectivity factor	polymer	176	20982.2	1	UniProt (P12504) Pfam (PF00559) In PDB	Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)	Vif,SOR protein
5	D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	polymer	486	56266.6	1	UniProt (Q15172) Pfam (PF01603) In PDB	Homo sapiens (human)	PP2A B subunit isoform B'-alpha,PP2A B subunit isoform B56-alpha,PP2A B subunit isoform PR61-alpha,PR61alpha,PP2A B subunit isoform R5-alpha

Sequence modifications

C: 1 - 187 (UniProt: Q13951)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	124884.2
All*	Total formula weight	124884.2

*Water molecules are not included.