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8SZK

The cryo-EM structure of PPP2R5A/HIV-1 Vif/CBFb/EloB/EloC complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001222molecular_functiontranscription corepressor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0016567biological_processprotein ubiquitination
A0030891cellular_componentVCB complex
A0031462cellular_componentCul2-RING ubiquitin ligase complex
A0031466cellular_componentCul5-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0065003biological_processprotein-containing complex assembly
A0070449cellular_componentelongin complex
A0140958biological_processtarget-directed miRNA degradation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000209biological_processprotein polyubiquitination
C0001503biological_processossification
C0001649biological_processosteoblast differentiation
C0003677molecular_functionDNA binding
C0003713molecular_functiontranscription coactivator activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0016020cellular_componentmembrane
C0016513cellular_componentcore-binding factor complex
C0030098biological_processlymphocyte differentiation
C0030099biological_processmyeloid cell differentiation
C0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
C0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
C0043565molecular_functionsequence-specific DNA binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048469biological_processcell maturation
C0060216biological_processdefinitive hemopoiesis
D0000159cellular_componentprotein phosphatase type 2A complex
D0000775cellular_componentchromosome, centromeric region
D0004721molecular_functionphosphoprotein phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006470biological_processprotein dephosphorylation
D0019888molecular_functionprotein phosphatase regulator activity
D0019900molecular_functionkinase binding
D0030018cellular_componentZ disc
D0031430cellular_componentM band
D0035307biological_processpositive regulation of protein dephosphorylation
D0072542molecular_functionprotein phosphatase activator activity
D0090219biological_processnegative regulation of lipid kinase activity
D1903077biological_processnegative regulation of protein localization to plasma membrane
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0016020cellular_componentmembrane
G0020002cellular_componenthost cell plasma membrane
G0030430cellular_componenthost cell cytoplasm
G0044423cellular_componentvirion component
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895
ChainResidueDetails
DSER2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER41
DSER42

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER49
ASER111

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081
ChainResidueDetails
GSER165

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PDB entries from 2024-07-17

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