8SZI
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C | Guanine nucleotide-binding protein G(i) subunit alpha-3 | polymer | 354 | 40584.2 | 1 | UniProt (P08754) Pfam (PF00503) In PDB | Homo sapiens (human) | G(i) alpha-3 |
2 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 343 | 37574.0 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
3 | E | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | A | Extracellular calcium-sensing receptor | polymer | 939 | 105938.8 | 1 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
5 | B | Extracellular calcium-sensing receptor | polymer | 959 | 108023.1 | 1 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
6 | F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
7 | A, B | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 2 | Chemie (PCW) | |||
8 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
9 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
10 | A, B | TRYPTOPHAN | non-polymer | 204.2 | 3 | Chemie (TRP) | |||
11 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
12 | B | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
C: 1 - 354 (UniProt: P08754)
D: 2 - 340 (UniProt: P62873)
A: 19 - 894 (UniProt: P41180)
B: 19 - 894 (UniProt: P41180)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 9 | - | expression tag |
Tyr 10 | - | expression tag |
Lys 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Asp 15 | - | expression tag |
Lys 16 | - | expression tag |
Ala 17 | - | expression tag |
Ala 18 | - | expression tag |
Thr 895 | - | expression tag |
Ser 896 | - | expression tag |
Thr 897 | - | expression tag |
Ser 898 | - | expression tag |
Val 899 | - | expression tag |
Thr 900 | - | expression tag |
Ser 901 | - | expression tag |
Val 902 | - | expression tag |
Asn 903 | - | expression tag |
Gln 904 | - | expression tag |
Ala 905 | - | expression tag |
Ser 906 | - | expression tag |
Thr 907 | - | expression tag |
Ser 908 | - | expression tag |
Arg 909 | - | expression tag |
Leu 910 | - | expression tag |
Glu 911 | - | expression tag |
Gly 912 | - | expression tag |
Leu 913 | - | expression tag |
Gln 914 | - | expression tag |
Ser 915 | - | expression tag |
Glu 916 | - | expression tag |
Asn 917 | - | expression tag |
His 918 | - | expression tag |
Arg 919 | - | expression tag |
Leu 920 | - | expression tag |
Arg 921 | - | expression tag |
Met 922 | - | expression tag |
Lys 923 | - | expression tag |
Ile 924 | - | expression tag |
Thr 925 | - | expression tag |
Glu 926 | - | expression tag |
Leu 927 | - | expression tag |
Asp 928 | - | expression tag |
Lys 929 | - | expression tag |
Asp 930 | - | expression tag |
Leu 931 | - | expression tag |
Glu 932 | - | expression tag |
Glu 933 | - | expression tag |
Val 934 | - | expression tag |
Thr 935 | - | expression tag |
Met 936 | - | expression tag |
Gln 937 | - | expression tag |
Leu 938 | - | expression tag |
Gln 939 | - | expression tag |
Asp 940 | - | expression tag |
Thr 941 | - | expression tag |
Pro 942 | - | expression tag |
Glu 943 | - | expression tag |
Lys 944 | - | expression tag |
Lys 945 | - | expression tag |
Thr 946 | - | expression tag |
Asn 947 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp -13 | - | expression tag |
Ser -12 | - | expression tag |
His -11 | - | expression tag |
Pro -10 | - | expression tag |
Gln -9 | - | expression tag |
Phe -8 | - | expression tag |
Glu -7 | - | expression tag |
Lys -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Gly 3 | - | expression tag |
Gly 4 | - | expression tag |
Ser 5 | - | expression tag |
Ala 6 | - | expression tag |
Trp 7 | - | expression tag |
Ser 8 | - | expression tag |
His 9 | - | expression tag |
Pro 10 | - | expression tag |
Gln 11 | - | expression tag |
Phe 12 | - | expression tag |
Glu 13 | - | expression tag |
Lys 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
Ala 17 | - | expression tag |
Ala 18 | - | expression tag |
Thr 895 | - | expression tag |
Gly 896 | - | expression tag |
Ser 897 | - | expression tag |
Ser 898 | - | expression tag |
Thr 899 | - | expression tag |
Asn 900 | - | expression tag |
Asn 901 | - | expression tag |
Asn 902 | - | expression tag |
Glu 903 | - | expression tag |
Glu 904 | - | expression tag |
Glu 905 | - | expression tag |
Lys 906 | - | expression tag |
Ser 907 | - | expression tag |
Arg 908 | - | expression tag |
Leu 909 | - | expression tag |
Leu 910 | - | expression tag |
Glu 911 | - | expression tag |
Lys 912 | - | expression tag |
Glu 913 | - | expression tag |
Asn 914 | - | expression tag |
Arg 915 | - | expression tag |
Glu 916 | - | expression tag |
Leu 917 | - | expression tag |
Glu 918 | - | expression tag |
Lys 919 | - | expression tag |
Ile 920 | - | expression tag |
Ile 921 | - | expression tag |
Ala 922 | - | expression tag |
Glu 923 | - | expression tag |
Lys 924 | - | expression tag |
Glu 925 | - | expression tag |
Glu 926 | - | expression tag |
Arg 927 | - | expression tag |
Val 928 | - | expression tag |
Ser 929 | - | expression tag |
Glu 930 | - | expression tag |
Leu 931 | - | expression tag |
Arg 932 | - | expression tag |
His 933 | - | expression tag |
Gln 934 | - | expression tag |
Leu 935 | - | expression tag |
Gln 936 | - | expression tag |
Ser 937 | - | expression tag |
Arg 938 | - | expression tag |
Gln 939 | - | expression tag |
Gln 940 | - | expression tag |
Leu 941 | - | expression tag |
Lys 942 | - | expression tag |
Lys 943 | - | expression tag |
Thr 944 | - | expression tag |
Asn 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 299981.1 | |
Branched | Number of molecules | 3 |
Total formula weight | 1273.2 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 3587.4 | |
All* | Total formula weight | 304841.8 |