8SZI
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0001664 | molecular_function | G protein-coupled receptor binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005813 | cellular_component | centrosome |
| C | 0005829 | cellular_component | cytosol |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| C | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| C | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016239 | biological_process | positive regulation of macroautophagy |
| C | 0019001 | molecular_function | guanyl nucleotide binding |
| C | 0019003 | molecular_function | GDP binding |
| C | 0030496 | cellular_component | midbody |
| C | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| C | 0034451 | cellular_component | centriolar satellite |
| C | 0036064 | cellular_component | ciliary basal body |
| C | 0046039 | biological_process | GTP metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051301 | biological_process | cell division |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0001750 | cellular_component | photoreceptor outer segment |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005765 | cellular_component | lysosomal membrane |
| D | 0005829 | cellular_component | cytosol |
| D | 0005834 | cellular_component | heterotrimeric G-protein complex |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007165 | biological_process | signal transduction |
| D | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| D | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| D | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| D | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| D | 0007265 | biological_process | Ras protein signal transduction |
| D | 0008283 | biological_process | cell population proliferation |
| D | 0016020 | cellular_component | membrane |
| D | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0045202 | cellular_component | synapse |
| D | 0050909 | biological_process | sensory perception of taste |
| D | 0051020 | molecular_function | GTPase binding |
| D | 0060041 | biological_process | retina development in camera-type eye |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| D | 0071870 | biological_process | cellular response to catecholamine stimulus |
| D | 0097381 | cellular_component | photoreceptor disc membrane |
| D | 1903561 | cellular_component | extracellular vesicle |
| E | 0005515 | molecular_function | protein binding |
| E | 0005834 | cellular_component | heterotrimeric G-protein complex |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007165 | biological_process | signal transduction |
| E | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| E | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| E | 0016020 | cellular_component | membrane |
| E | 0031681 | molecular_function | G-protein beta-subunit binding |
| E | 0045202 | cellular_component | synapse |
| E | 0048144 | biological_process | fibroblast proliferation |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| E | 0071870 | biological_process | cellular response to catecholamine stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| D | LEU70-SER84 | |
| D | ILE157-ILE171 | |
| D | LEU285-ALA299 |
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS |
| Chain | Residue | Details |
| A | VAL153-SER171 | |
| B | VAL153-SER171 |
| site_id | PS00980 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC |
| Chain | Residue | Details |
| A | CYS561-CYS585 | |
| B | CYS561-CYS585 |
| site_id | PS00981 |
| Number of Residues | 11 |
| Details | G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM |
| Chain | Residue | Details |
| A | PHE801-MET811 | |
| B | PHE801-MET811 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19478087","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IHB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ODE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V4Z","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 75 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 62 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 270 |
| Details | Region: {"description":"Ligand-binding 2 (LB2)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 140 |
| Details | Region: {"description":"Cysteine-rich (CR)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 22 |
| Details | Region: {"description":"Intracellular loop 1 (ICL1)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 23 |
| Details | Region: {"description":"Intracellular loop 2 (ICL2)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 30 |
| Details | Region: {"description":"Intracellular loop 3 (ICL3)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI36 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI37 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI39 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI40 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI41 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI42 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI43 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI44 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI45 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity","evidences":[{"source":"PubMed","id":"26290606","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI46 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI47 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI48 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
